{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:21:40Z","timestamp":1787502100755,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>A 31\u2010year\u2010old female with a diagnosis of bipolar disorder developed black hairy tongue after alprazolam therapy. Her symptom resolved 10\u2009days after the cessation of alprazolam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Alprazolam is a widely used antidepressant and antianxiety drug. Mild to moderate side effect of alprazolam was commonly seen, including lethargy, dizziness, headache, dry mouth, nausea, fatigue, constipation, and blurred vision. In this case, we reported a patient developed black hairy tongue after alprazolam intake, and her symptom resolved after 10\u2010day discontinuation of alprazolam. This rare adverse event should be of concern to clinicians. This is the first paper to report an alprazolam\u2010induced BHT. This rare side effect of alprazolam should be concern of clinicians; we hope our report will promote the understand of BHT and acknowledge clinicians of this rare side effect of alprazolam.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.7831","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:31:35Z","timestamp":1692847895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Black hairy tongue after alprazolam intake"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0288-8015","authenticated-orcid":false,"given":"Long","family":"Jiang","sequence":"first","affiliation":[{"name":"The Mental Health Center and the Psychiatric Laboratory West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"The Mental Health Center and the Psychiatric Laboratory West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tan","sequence":"additional","affiliation":[{"name":"The Mental Health Center and the Psychiatric Laboratory West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Tang","sequence":"additional","affiliation":[{"name":"The Mental Health Center and the Psychiatric Laboratory West China Hospital, Sichuan University  Chengdu China"},{"name":"Sleep Medicine Center Mental Health Center, and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Alprazolam","author":"George 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black hairy tongue","volume":"89","author":"Braggio C","year":"2018","journal-title":"Acta Biomed"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13309"},{"issue":"6","key":"e_1_2_14_19_1","first-page":"653","article-title":"Linezolid induced black hairy tongue","volume":"56","author":"Balaji G","year":"2014","journal-title":"Indian J Pharmacol"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03641-9"},{"issue":"6","key":"e_1_2_14_21_1","first-page":"891","article-title":"Black hairy tongue associated with olanzapine treatment: a case report","volume":"73","author":"Tamam L","year":"2006","journal-title":"Mt Sinai J Med"}],"container-title":["Clinical Case 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