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The HPV test and pathology results indicated the presence of independent HPV in primary serous carcinoma of the uterine cervix. The genetic testing identified variants of uncertain significance (PAX8 p.Tyr 410 Ter and TP53 p.Asn 247 Ile), microsatellite instability stable (MSI\u2010S), tumor mutational burden (TMB) 7.33Muts\/Mb, and an elevated tumor neoantigen burden. Before undergoing radical hysterectomy treatment, the patient exhibited a positive response to three cycles of intravenous docetaxel (100\u2009mg\/3\u2009h) and carboplatin (450\u2009mg\/1\u2009h). Following the surgery, she received an additional three cycles of docetaxel (100\u2009mg\/3\u2009h) and carboplatin (500\u2009mg\/1\u2009h), accompanied by 25\u2009cycles of radiation therapy (DT 46Gy\/2Gy\/23f). Concurrently, cisplatin (450\u2009mg\/1\u2009h) was administered. As of now, the patient has achieved 20\u2009months of disease\u2010free survival.<\/jats:p>","DOI":"10.1002\/ccr3.7833","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:30:30Z","timestamp":1693441830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular pathology and clinical treatment of independent <scp>HPV<\/scp> primary serous carcinoma of the uterine cervix (USCC): A case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Lina","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Gynecology Yuncheng Central Hospital, Shanxi Province  Yuncheng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangying","family":"Ruan","sequence":"additional","affiliation":[{"name":"Zhejiang Shaoxing Topgen Biomedical Technology Co., Ltd  Shanghai 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