{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:27:52Z","timestamp":1768807672638,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>SARS\u2010CoV\u20102 infection has been associated with a prolonged course and a poor prognosis in patients who receive anti\u2010CD20 antibodies. However, there are no established treatments for such patients. Serial changes in the SARS\u2010CoV\u20102 antigen titer during the clinical course and treatment strategies for immunosuppressed patients are discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>We report a case of prolonged SARS\u2010CoV\u20102 infection during obinutuzumab and bendamustine treatment for follicular lymphoma. Four years previously, the patient had been diagnosed with follicular lymphoma (Stage IIIA, Grade 2). She received several chemotherapy regimens, including rituximab and radiation therapy. Although these therapies achieved complete response temporally, they did not continue and recurred at 8\u2009months before. Obinutuzumab and bendamustine therapy was selected, and she received five courses of obinutuzumab and bendamustine. She also received a SARS\u2010CoV\u20102 mRNA vaccine two times. Although she did not have any symptoms, a routine check\u2010up just before the 6th course of obinutuzumab and bendamustine revealed SARS\u2010CoV\u20102 infection. Because she was immunosuppressed and was considered to be at high risk for the exacerbation of her disease, molnupiravir was immediately administered, and her SARS\u2010CoV\u20102 antigen decreased. However, it was not completely cleared and flared\u2010up at 6\u2009weeks, with symptoms of COVID\u201019 appearing. Despite intensive treatment for SARS\u2010CoV\u20102 infection, including remdesivir, baricitinib, tocilizumab and intravenous immunoglobulin, her SARS\u2010CoV\u20102 antigen titer never became negative, and she finally died of respiratory failure caused by prolonged SARS\u2010CoV\u20102 infection. Serial changes in the SARS\u2010CoV\u20102 antigen titer during the clinical course and treatment strategies for immunosuppressed patients are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7861","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:20:30Z","timestamp":1693268430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prolonged <scp>SARS\u2010CoV<\/scp>\u20102 infection during obinutuzumab and bendamustine treatment for follicular lymphoma: A case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Ryosuke","family":"Kambe","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine National Hospital Organization Takasaki General Medical Center  Takasaki Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine National Hospital Organization Takasaki General Medical Center  Takasaki Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine National Hospital Organization Takasaki General Medical Center  Takasaki Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine National Hospital Organization Takasaki General Medical Center  Takasaki Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-7093","authenticated-orcid":false,"given":"Satoru","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Research National Hospital Organization Takasaki General Medical Center  Takasaki Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr2105280"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2206573"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108867"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad276"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14112377"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9136-21"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.08.017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.07.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-023-02039-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18315"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2022-0112"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0612-x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1957877"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.077"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcvp.2023.100151"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13150"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15010118"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:56:38Z","timestamp":1754027798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/ccr3.7861"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7861","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]},"assertion":[{"value":"2023-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7861"}}