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IgG4\u2010related retroperitoneal fibrosis (IgG4\u2010RPF) is a rare form of IgG4\u2010RD, diagnosis of which is often relied on radiological technology. Herein, we describe a case of 60\u2009year old male, presenting with low back pain and weight loss for a period of 2\u2009months and 15\u2009days. Imaging studies showed a retroperitoneal tumorous mass along with bilateral hydroureteronephrosis, which was later confirmed to be IgG4\u2010related retroperitoneal fibrosis on the basis of extensive histopathological analysis. Immunosuppressive therapy resulted in a decrease in fibrosis and restoration of renal function.<\/jats:p>","DOI":"10.1002\/ccr3.7865","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:32:26Z","timestamp":1693441946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>IgG4<\/scp>\u2010related retroperitoneal fibrosis: A case report of a challenging disease"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3761-1705","authenticated-orcid":false,"given":"Saika","family":"Farook","sequence":"first","affiliation":[{"name":"Department of Microbiology Ibrahim Medical College  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shariful Alam","family":"Jilani","sequence":"additional","affiliation":[{"name":"Department of Microbiology Ibrahim Medical College  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Kamrul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Urology Dhaka Medical College and Hospital &amp; Department of Urology, Centre for Kidney Disease &amp; Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamima","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Colonel Malek Medical College and Hospital, Manikganj University of Dhaka  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumana","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Dr. Sirajul Islam Medical College &amp; Hospital Ltd  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naval","family":"Mendiratta","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Fortis Memorial Research Institute  Gurugram 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