{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:05:42Z","timestamp":1754093142715,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:p>We present a case of a 60\u2010year\u2010old male diagnosed with metastatic clear cell renal cell carcinoma who developed hypoglycemia during induction ipilimumab and nivolumab treatment. This was diagnosed as presumed type 1 diabetes mellitus secondary to immunotherapy.<\/jats:p>","DOI":"10.1002\/ccr3.7897","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:11Z","timestamp":1694131211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypoglycemia as first presentation of presumed immune checkpoint inhibitor\u2010induced type 1 diabetes"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0952-1449","authenticated-orcid":false,"given":"Rayyan Syed","family":"Kamal","sequence":"first","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University  London Ontario Canada"},{"name":"Cancer Research Laboratory Program, Lawson Health Research Institute London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1188-5943","authenticated-orcid":false,"given":"Arleigh","family":"Dean","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University  London Ontario Canada"},{"name":"Cancer Research Laboratory Program, Lawson Health Research Institute London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8743-6284","authenticated-orcid":false,"given":"Hanna","family":"Dutt","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University  London Ontario Canada"},{"name":"Cancer Research Laboratory Program, Lawson Health Research Institute London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Rajeh","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University  London Ontario Canada"},{"name":"Department of Oncology, Division of Medical Oncology, Schulich School of Medicine &amp; Dentistry Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-8246","authenticated-orcid":false,"given":"Ricardo","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Oncology, Division of Medical Oncology, Schulich School of Medicine &amp; Dentistry Western University  London Ontario Canada"},{"name":"Cancer Research Laboratory Program Lawson Health Research Institute  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910836"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30413-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160221"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1703481"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2018-000591"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30074-8"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.3064"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000972"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi18-0002"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00423"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.12.10.773"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:57:10Z","timestamp":1754027830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/ccr3.7897"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7897","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7897"}}