{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:36:41Z","timestamp":1773175001427,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Key clinical message<\/jats:title><jats:p>PB19 infection should be considered an uncommon cause of posttransplant anemia in renal transplant recipients, particularly those whose anemia is not associated with common etiologies. IVIG treatment and reduced immunosuppression could be beneficial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Parvovirus B19\u2010associated relapsing anemia is rare in kidney transplant recipients. Herein, we report a case of relapsed anemia due to parvovirus B19 infection in a 53\u2010year\u2010old woman 18\u2009months after kidney transplantation. The patient presented with palpitations, shortness of breath, dizziness, weakness, and lethargy. Early laboratory findings showed a WBC count of 6.000\/\u03bcL, RBC count of 1.89\/\u03bcL, hemoglobin (Hb) 3.5\u2009g\/dL, hematocrit (Hct) 15%, platelet count 266.000\/\u03bcL, MCV 89, reticulocyte count 0.8%, and serum iron 221\u2009\u03bcg\/dL. Upon further evaluation, the RT\u2010PCR test for BK polyomavirus and cytomegalovirus (CMV) was negative, while the parvovirus B19 RT\u2010PCR was positive. The patient was treated with blood transfusion and IVIG 25\u2009g daily for 5\u2009days. Two months after discharge, the patient presented, complaining of palpitation, shortness of breath, and dizziness, with RBC 2.7\/\u03bcL, Hb 6.5\u2009g\/dL, Hct 25%, and MCV 85. Again, the CMV RT\u2010PCR was negative, while the parvovirus B19 RT\u2010PCR was positive. Tacrolimus and mycophenolic acid were stopped, and IVIG 25\u2009g daily for 5\u2009days was administered. Consequently, her Hb level increased to 9\u2009g\/dL, and the patient was discharged with prednisolone 5\u2009mg daily and cyclosporine 50\u2009mg daily instead of tacrolimus. Viral infection, particularly PB19 infection, should be considered in the differential diagnosis of posttransplantation anemia in KTRs. IVIG treatment and modification of immunosuppressive medications are suggested standard therapies for such patients. The function of transplanted kidneys should be carefully monitored during treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7906","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:28Z","timestamp":1694131228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Relapsing anemia associated with parvovirus <scp>B19<\/scp> infection in a kidney transplant recipient: A case report and review of the literature"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3120-7111","authenticated-orcid":false,"given":"Fatemeh","family":"Yaghoubi","sequence":"first","affiliation":[{"name":"Nephrology Research Center, Shariati Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davood","family":"Dalil","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Shahed University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-1488","authenticated-orcid":false,"given":"Farnaz","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Nephrology Research Center, Shariati Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyyed Mohammad","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Shahed University  Tehran 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