{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:05:40Z","timestamp":1754093140400,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:p>The incidence of syphilis in young children is very low, with acquired syphilis exceptionally rare. A 3\u2009year\u2010old girl presented to our service with a reddish\u2010brown rash on the external genitals and perianal area. The rash had been apparent for a period of 1\u2009week. The girl was asymptomatic and had no history of sexual contact. Syphilis was suspected and the <jats:italic>Treponema pallidum<\/jats:italic> particle agglutination test (TPPA) was found to be positive, as well as the rapid plasma regin ring card test (RPR), with a titer of 1:64. The girl was diagnosed with toddler acquired secondary syphilis. The girl was cured after three treatments with penicillin. This report points out the need for clinicians to be aware of nonsexually transmitted syphilis, acquired in daily life by children without a history of sexual contact.<\/jats:p>","DOI":"10.1002\/ccr3.7959","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T01:42:18Z","timestamp":1695692538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acquired syphilis with flat condyloma in a 3\u2009year\u2010old girl: A case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Qing\u2010fu","family":"Hu","sequence":"first","affiliation":[{"name":"Department of General Practice The Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-9920","authenticated-orcid":false,"given":"Kun\u2010jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"volume-title":"WHO Guidelines for the Treatment of Treponema Pallidum (Syphilis)","year":"2016","author":"World Health Organization","key":"e_1_2_9_2_1"},{"issue":"8","key":"e_1_2_9_3_1","first-page":"668","article-title":"Trends and characteristics of syphilis epidemic in China from 2014 to 2019","volume":"54","author":"Yue X","year":"2021","journal-title":"Chin J Dermatol"},{"key":"e_1_2_9_4_1","first-page":"168","article-title":"Guidelines for the diagnosis and treatment of syphilis, gonorrhea and genital chlamydia trachomatis infection","volume":"03","author":"National Center for STD Control, Chinese Center for Disease Control and Prevention; Venereology Group, Chinese Society of Dermatology; Subcommittee on Venereology, China Dermatologist Association","year":"2020","journal-title":"Chin J Dermatol"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.25259\/IJDVL_748_2021"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1186\/s12879-021-06114-7"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:56:17Z","timestamp":1754027777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/ccr3.7959"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7959","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7959"}}