{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:00:58Z","timestamp":1765382458796,"version":"3.46.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,10]]},"abstract":"\n Key Clinical Message<\/jats:title>\n Choriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be evaluated for choriocarcinoma based on histopathological findings. Adjuvant chemotherapy (after surgery) is the proposed treatment for tubal choriocarcinoma.<\/jats:p>\n <\/jats:sec>\n \n Abstract<\/jats:title>\n Choriocarcinoma is a malignant epithelial tumor of the chorionic villi that often manifests after a normal or molar pregnancy. The primary tubal choriocarcinoma associated with ectopic pregnancy is extremely rare and can be misdiagnosed as an ectopic pregnancy since symptoms including vaginal bleeding, amenorrhea, elevated beta\u2010human chorionic gonadotropin (BHCG) levels, and pelvic pain are shared. A 34\u2010year\u2010old G4P3003 woman presented with a one\u2010week history of vaginal bleeding and right lower abdominal pain, which had intensified a day before admission. Clinical and paraclinical examinations pointed to a ruptured tubal pregnancy; hence, an emergency laparotomy was performed, and a right salpingectomy was carried out on the patient. However, a nonsignificant decline in BHCG level was observed, and histological examination revealed tubal choriocarcinoma; hence, a metastasis workup was carried out, yet no metastasis was detected. Six sessions of chemotherapy consisting of Etoposide, Methotrexate, Dactinomycin, Cyclophosphamide, and Vincristine (EMA\u2010CO) were administered without complication, in such a way that the BHCG level normalized after three sessions of chemotherapy. Evaluations after 1\u2009year from the completion of chemotherapy revealed that the patient had no subsequent problems. Choriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be evaluated for choriocarcinoma based on histopathological findings. Metastasis workup should be considered for all individuals with choriocarcinoma. Adjuvant chemotherapy (after surgery) is the proposed treatment for tubal choriocarcinoma.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ccr3.7977","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T21:43:46Z","timestamp":1695851026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Choriocarcinoma in tubal pregnancy: A case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Fateme Sadat","family":"Najib","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Oncology Gynecology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Infertility Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samaneh","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Oncology Gynecology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Obstetrics and Gynecology, Division of Perinatology, Imam Khomeini Hospital Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Shiravani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Oncology Gynecology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Maternal\u2010Fetal Medicine Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-6691","authenticated-orcid":false,"given":"Seyed Mohammad Amin","family":"Alavi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-006318"},{"key":"e_1_2_11_3_1","first-page":"QD17","article-title":"Primary tubal choriocarcinoma presented as ruptured ectopic pregnancy","volume":"9","author":"Karaman E","year":"2015","journal-title":"J Clin Diagn 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