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Herein we report a 30\u2010year\u2010old immunocompetent man who presented with fever, sore throat, general weakness, and drowsiness. The diagnosis was formulated based on the positive RT\u2010PCR test for EBV DNA and serological detection of IgM antibody against viral capsid antigen. The patient developed severe meningoencephalitis, myocarditis, and bowel perforation and passed away after 72\u2009days of hospitalization.<\/jats:p>","DOI":"10.1002\/ccr3.7993","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T23:49:28Z","timestamp":1696636168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epstein\u2013Barr virus infection leading to multiorgan involvement in an immunocompetent man"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2539-9516","authenticated-orcid":false,"given":"Saina","family":"Paymannejad","sequence":"first","affiliation":[{"name":"School of medicine Isfahan university of medical sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiana","family":"Shirani","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center Isfahan 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