{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:25:08Z","timestamp":1764253508592,"version":"3.46.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>COVID 19 is a serious infection that originated in Wuhan, China and has resulted in worldwide morbidity and mortality. It continues to be a major health concern in 2022, being associated with multiorgan failure. Although the pathophysiology of the disease and its complications are not well understood, it is believed that a cytokine storm, triggered by complement activation may be responsible for the severity and complications of the disease. As of now, there is no definitive treatment available. Hematological changes associated with COVID\u201019 include lymphopenia, anemia, thrombocytopenia, disseminated intravascular coagulopathy, and thrombosis. Paroxysmal nocturnal hemoglobinuria (PNH), on the other hand, is an acquired clonal hematopoietic stem cell disorder that occurs due to an acquired PIG\u2010A mutation affecting the hematopoietic stem cells. Interestingly, PNH exhibits some clinical and laboratory manifestations like those seen in COVID\u201019. In this report, we present a rare case of PNH that developed following a COVID\u201019 infection.<\/jats:p>","DOI":"10.1002\/ccr3.8011","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:42:39Z","timestamp":1696902159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paroxysmal nocturnal hemoglobinuria in a patient post\n                    <scp>COVID<\/scp>\n                    \u201019 virus infection: A case report with literature review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-3221","authenticated-orcid":false,"given":"Mohammed","family":"Albalawi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Taibah University  Madinah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turki","family":"Alwasaidi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Taibah University  Madinah Saudi Arabia"},{"name":"Medicine Department Prince Mohammed Bin Abdul\u2010Aziz Hospital\u2010National Guard Hospital  Madinah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Almohammadi","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences, Pathology and Laboratory Medicine, King Abdulaziz Medical City  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf Ahmad","family":"Alzarief","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-4500","authenticated-orcid":false,"given":"Ghaleb","family":"Elyamany","sequence":"additional","affiliation":[{"name":"Central Military Laboratory and Blood Bank Prince Sultan Military Medical City  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.03.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-00646-x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140711"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.06.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510178"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000644"},{"key":"e_1_2_10_8_1","first-page":"259","article-title":"Paroxysmal nocturnal haemoglobinuria","volume":"8","author":"Saevels K","year":"2017","journal-title":"Br J Hematol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-013-0272-1"},{"issue":"4","key":"e_1_2_10_10_1","first-page":"355","article-title":"Flow cytometric diagnosis of paroxysmal nocturnal hemoglobinuria: pearls and pitfalls\u2013a critical review article","volume":"30","author":"Brando B","year":"2019","journal-title":"eJIFCC"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.31.3.304"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:22:12Z","timestamp":1764253332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/ccr3.8011"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8011","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2022-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8011"}}