{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:55:21Z","timestamp":1784372121318,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>Peripheral eosinophilia is a rare but potential sign of TB infection. Physicians should assess patients for TB, especially if they display related symptoms or risk factors, and consider TB as a differential diagnosis, especially in idiopathic cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Millions of new tuberculosis (TB) cases are reported annually. Peripheral eosinophilia is rare in tuberculosis. We describe a rare case of tuberculosis with a high peripheral eosinophil count. A 9\u2010year\u2010old male presented with fever, cough, and respiratory discomfort for a month. The patient's cough did not respond to treatment, along with weight loss and a loss of appetite. A physical examination revealed cervical lymphadenopathy and bilateral lung crepitations. A hematological investigation showed a high eosinophil count of 25,920 cells per cubic millimeter and medical imaging abnormalities consistent with TB. Some malignancies, allergies, and parasitic infections produce peripheral eosinophilia. However, medical literature rarely discusses TB\u2010induced eosinophilia. Several studies attribute it to mycobacterium antigen hyperreactivity. Eosinophilic release of cytotoxic chemicals may cause tissue damage, and TB patients' eosinophil levels may fluctuate. This case report emphasizes the need to investigate TB in peripheral eosinophilia patients after ruling out other explanations. Our patient benefited from early detection and anti\u2010TB medication. More studies are required to investigate the causes of TB eosinophilia and its consequences. A detailed medical history and physical examination are essential to diagnose and treat atypical presentations of TB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8085","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:02:49Z","timestamp":1698109369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tuberculosis manifesting with significant peripheral eosinophilia: A case report and review of literature"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1693-5648","authenticated-orcid":false,"given":"Abhiram Rao","family":"Damera","sequence":"first","affiliation":[{"name":"Mediciti Institute of Medical Sciences  Ghanpur Telangana India"},{"name":"Team Erevnites  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-3769","authenticated-orcid":false,"given":"Prakash","family":"Gupta","sequence":"additional","affiliation":[{"name":"Team Erevnites  India"},{"name":"Virgen Milagrosa University Foundation College of Medicine  San Carlos Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-2906","authenticated-orcid":false,"given":"Shaheer","family":"Farooqi","sequence":"additional","affiliation":[{"name":"Team Erevnites  India"},{"name":"Department of Medicine Ziauddin University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0615-8397","authenticated-orcid":false,"given":"Vivek","family":"Sanker","sequence":"additional","affiliation":[{"name":"Team Erevnites  India"},{"name":"Noorul Islam Institute of Medical Sciences  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2097-7921","authenticated-orcid":false,"given":"Arpita Mariam","family":"Mathews","sequence":"additional","affiliation":[{"name":"Team Erevnites  India"},{"name":"Mount Zion Medical College  Pathanamthitta Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0458-7875","authenticated-orcid":false,"given":"Shreya","family":"Pampati","sequence":"additional","affiliation":[{"name":"Team Erevnites  India"},{"name":"Kamineni Institute of Medical Sciences  Narketpally Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6977-9532","authenticated-orcid":false,"given":"Manoj Reddy","family":"Allala","sequence":"additional","affiliation":[{"name":"Mediciti Institute of Medical Sciences  Ghanpur Telangana India"},{"name":"Team Erevnites  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-7333","authenticated-orcid":false,"given":"Tirth","family":"Dave","sequence":"additional","affiliation":[{"name":"Team Erevnites  India"},{"name":"Bukovinian State Medical University  Chernivtsi Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.4.16141"},{"key":"e_1_2_11_4_1","first-page":"78","article-title":"Hematological abnormalities in Saudis suffering from pulmonary tuberculosis and their response to the treatment","volume":"3","author":"Al\u2010Omar I","year":"2009","journal-title":"Res J Pharmacol Res"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"1","article-title":"The many faces of hepatic tuberculosis, 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