{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:33Z","timestamp":1753862853087,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Jacobs syndrome and congenital adrenal hyperplasia are separate entities but share common clinical features such as ambiguous genitalia. Further studies are needed to conclude the relationship between Jacobs syndrome and congenital adrenal hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>A 5\u2010month\u2010old male infant was evaluated for ambiguous genitalia. Examination revealed cryptorchidism, inguinal hernia, long phallus, and Grade 3 scrotal hypospadias. Serum 17\u2010OH progesterone was high and chromosomal analysis showed 47XYY\/45XO. A diagnosis of Jacobs and CAH was made. The parents were counseled about the patient's condition. He was given hydrocortisone and referred to the pediatric surgeon for further management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8097","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T07:46:05Z","timestamp":1699602365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Coexistence of Jacobs syndrome, congenital adrenal hyperplasia, and ambiguous genitalia in a male infant"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8660-9551","authenticated-orcid":false,"given":"Qaisar Ali","family":"Khan","sequence":"first","affiliation":[{"name":"Khyber Teaching Hospital MTI KTH  Peshawar Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiza","family":"Amatul\u2010Hadi","sequence":"additional","affiliation":[{"name":"Mercer University School of Medicine  Macon Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amritpal","family":"Kooner","sequence":"additional","affiliation":[{"name":"Chicago College of Osteopathic Medicine  Downers Grove Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Lee","sequence":"additional","affiliation":[{"name":"Arkansas College of Osteopathic Medicine  Fort Smith Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahma","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Kennesaw State University  Kennesaw Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adithya","family":"Nadella","sequence":"additional","affiliation":[{"name":"Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshawardhan","family":"Pande","sequence":"additional","affiliation":[{"name":"Saint Louis University  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7299-9741","authenticated-orcid":false,"given":"Yaxel","family":"Levin\u2010Carrion","sequence":"additional","affiliation":[{"name":"Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5280-3862","authenticated-orcid":false,"given":"Muhammad","family":"Afzal","sequence":"additional","affiliation":[{"name":"St. George's University School of Medicine  True Blue Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Long School of Medicine at the University of Texas Health Science Center San Antonio  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8529(08)70017-3"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"188","article-title":"47, XYY syndrome and male infertility","volume":"15","author":"Kim IW","year":"2013","journal-title":"Rev Urol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.616693"},{"volume-title":"Congenital Adrenal Hyperplasia. 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