{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:02Z","timestamp":1753862882171,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>An uncommon form of CNS tuberculosis called non\u2010osseous IDEM tuberculoma frequently results from paradoxical drug interactions. It should be considered one of the differentials when patients receiving ATT experience acute neurological impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Tuberculoma affecting the spinal cord is a rare condition in modern times. The occurrence of non\u2010osseous intradural tuberculosis, specifically in the spine, is even more exceptional. In fact, it is uncommon to encounter an intradural extramedullary tuberculous granuloma that lacks radiological indications of vertebral involvement, especially within the thoracic region. We present a case of a patient with a neurological deficit caused by a non\u2010osseous intradural tuberculoma in the thoracic region, without any associated bone involvement. The patient experienced a gradual deterioration of neurological function. An MRI of the thoracic spine revealed the presence of a tuberculoma located intradurally, extramedullary, and juxtamedullary of the T5 vertebra. The compression of the spinal cord resulted in paraparesis which was worsening to paraplegia. A D4\u2013D6 laminectomy and microsurgical excision were performed under intraoperative neurophysiological monitoring (IONM), and the patient showed clinical recovery. Excellent clinical outcomes were achieved. However, it is crucial to consider the possibility of a non\u2010osseous intradural tuberculoma as a rare condition when encountering a SOL, particularly in patients with a history of tuberculosis and spinal cord compression. In cases where a progressing neurological deficit is present, a combination of surgical intervention and anti\u2010tuberculous treatment should be considered as the optimal approach.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8131","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T03:53:17Z","timestamp":1698983597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010osseous intradural tuberculoma of the thoracic spine with compressive myelopathy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5074-6698","authenticated-orcid":false,"given":"Shyam","family":"Duvuru","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Apollo Specialty Hospitals  Madurai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0615-8397","authenticated-orcid":false,"given":"Vivek","family":"Sanker","sequence":"additional","affiliation":[{"name":"Team Erevnites  Trivandrum India"},{"name":"Research Assistant, Department of Neurosurgery Trivandrum Medical College  Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-1779","authenticated-orcid":false,"given":"Syed","family":"Naureen","sequence":"additional","affiliation":[{"name":"Team Erevnites  Trivandrum India"},{"name":"UT MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-3769","authenticated-orcid":false,"given":"Gupta","family":"Prakash","sequence":"additional","affiliation":[{"name":"Team Erevnites  Trivandrum India"},{"name":"Virgen Milagrosa University Foundation College of Medicine  San Carlos City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5814-6322","authenticated-orcid":false,"given":"Rajurkar","family":"Sanjana","sequence":"additional","affiliation":[{"name":"Team Erevnites  Trivandrum India"},{"name":"Datta Meghe Institute of Higher Education and Research JNMC  Wardha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-7333","authenticated-orcid":false,"given":"Tirth","family":"Dave","sequence":"additional","affiliation":[{"name":"Team Erevnites  Trivandrum India"},{"name":"Bukovinian State Medical University  Chernivtsi Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-011-1390-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-012-2337-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-009-0966-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199611000-00006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200210000-00016"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200009010-00020"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.66B3.6427232"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2007.03.015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2003.10.022"},{"key":"e_1_2_11_11_1","unstructured":"WoodM AndersonM.Chronic meningitis. 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