{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:48:36Z","timestamp":1790858916685,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Crigler\u2013Najjar syndrome type 2 should be suspected in any young patient presenting with isolated indirect hyperbilirubinemia where all other common etiologies have been excluded. It is a relatively benign condition that responds to phenobarbitone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Crigler\u2013Najjar syndrome (CNS) type 2 is an inborn cause of isolated indirect hyperbilirubinemia characterized by a partial deficiency of the enzyme uridine 5\u2032\u2010diphosphate\u2010glucuronosyltransferase (UGT) responsible for bilirubin conjugation. Typically, this condition is diagnosed based on clinical manifestations, supplemented by enzyme analysis if feasible, and exhibits a significant response to phenobarbitone, known for its enzyme\u2010inducing properties. In this case, we present a young male patient who had experienced recurrent isolated indirect hyperbilirubinemia since early childhood, with negative results in the hemolytic workup. The patient exhibited a UGT1A1 gene defect and demonstrated a highly favorable response to phenobarbitone treatment. The purpose of this report is to raise awareness among physicians about this benign condition and underscore the importance of avoiding unnecessary investigations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8176","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T04:25:15Z","timestamp":1699935915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A rare case of <scp>Crigler\u2013Najjar<\/scp> syndrome type 2: A case report and literature review"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-2293","authenticated-orcid":false,"given":"Divas","family":"Rijal","sequence":"first","affiliation":[{"name":"Department of Critical Care medicine Tribhuvan University Teaching Hospital, Maharajgunj Medical Campus  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-2786","authenticated-orcid":false,"given":"Prabhat","family":"Rijal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam Murti","family":"Bohare","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Sanjay","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandip","family":"Dhungel","sequence":"additional","affiliation":[{"name":"Nepalgunj Medical College  Nepalgunj 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