{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:48:54Z","timestamp":1778546934417,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:p>Retinal astrocytic hamartoma (RAH) is a benign glial tumor that may be present in patients with tuberous sclerosis (TS), contributing to the diagnosis of this syndrome. While hamartomas identified through indirect ophthalmoscopy are often large enough to affect vessels and optic disc anatomy, RAH not detected in previous fundoscopies may become apparent in optical coherence tomography (OCT). The purpose of this report was to describe and characterize RAH with OCT with swept\u2010source technology (OCT\u2010SS), aiming to establish a more comprehensive classification for these hamartomas due to their diverse presentations. Fundus examination of a 11\u2010year\u2010old girl revealed retinal tumors in both eyes. OCT\u2010SS confirmed the diagnosis of TS, revealing dome\u2010shaped hyperreflective masses at different stages of evolution. Lesion 1: maximum thickness (MT) of 336\u2009\u03bcm and ganglion cell layer disorganization. Lesion 2: MT of 438\u2009\u03bcm and preserved outer plexiform layer. Lesion 3: posterior shadow, MT of 1478\u2009\u03bcm and complete rupture of retinal anatomy. Lesion 4: MT of 342\u2009\u03bcm and preserved retinal anatomy. OCT is a noninvasive method which assists the diagnosis of subclinical lesions and clinical characterization of TS patients.<\/jats:p>","DOI":"10.1002\/ccr3.8185","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:40:03Z","timestamp":1700570403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retinal hamartomas at different stages in a patient with tuberous sclerosis: A OCT\u2010SS description"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3163-8854","authenticated-orcid":false,"given":"Paula Basso","family":"Dias","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-5078","authenticated-orcid":false,"given":"Anna Carolina Badotti","family":"Linhares","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-6833","authenticated-orcid":false,"given":"Kenzo","family":"Hokazono","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.032"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.08.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2020.10.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aopr.2022.10.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000829"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001373"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12806"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.4.420"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-019-04476-y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120672118787441"},{"key":"e_1_2_11_12_1","first-page":"1537","article-title":"Non\u2010symmetry in the calibre of retinal blood vessels","volume":"9","author":"Gao L","year":"2009","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.03.023"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:23:48Z","timestamp":1702445028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/ccr3.8185"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8185","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8185"}}