{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:54Z","timestamp":1753862874816,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>The association of familial Mediterranean fever and ankylosing spondylitis is rare, but it is essential to consider this diagnosis in patients with a history of FMF who develop symptoms of back pain or other rheumatologic conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Familial Mediterranean fever (FMF) is an inherited inflammatory disorder characterized by recurrent fever episodes, abdominal pain, and arthralgia. Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the spine's joints. The association of FMF and AS is rare. We report the case of a 22\u2010year\u2010old male patient with a history of FMF and a positive family history of FMF in his father, who presented with inflammatory back pain. The patient was found to have sacroiliitis on MRI, which is a characteristic feature of AS. The patient was negative for HLA\u2010B27, a genetic marker often associated with AS. This case report highlights the importance of considering AS in patients with a history of FMF who develop back pain symptoms or other rheumatologic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8197","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T04:52:11Z","timestamp":1700023931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of familial Mediterranean fever presenting with ankylosing spondylitis: A rare case\u2010report"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-1683","authenticated-orcid":false,"given":"Amirreza","family":"Khalaji","sequence":"first","affiliation":[{"name":"Immunology Research Center Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3555-8908","authenticated-orcid":false,"given":"Mehdi","family":"Jafarpour","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.3390\/ijms24119584"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1007\/s10067-017-3715-5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1016\/j.ejr.2017.12.002"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1007\/s00296-004-0471-z"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1007\/s10067-008-0980-3"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1038\/s41413-019-0057-8"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.3344\/kjp.2020.33.4.294"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1016\/S0049-0172(97)80007-8"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1111\/ijcp.13645"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1186\/ar4154"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1016\/S0092-8674(00)80539-5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1038\/ng0997-25"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1002\/1529-0131(200106)44:6<1416::AID-ART236>3.0.CO;2-6"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1097\/01.md.0000152370.84628.0c"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1038\/sj.ejhg.5200674"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1038\/sj.ejhg.5200446"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.5606\/ArchRheumatol.2016.5671"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.4081\/cp.2011.e34"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:22:28Z","timestamp":1702444948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/ccr3.8197"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8197","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8197"}}