{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:29:51Z","timestamp":1785886191437,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T00:00:00Z","timestamp":1700870400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>This case highlights a potential association between influenza vaccination and the development of eosinophilic granulomatosis with polyangiitis (EGPA), prompting the need for increased vigilance regarding vaccine\u2010related autoimmune reactions. While causality remains unclear, clinicians should consider this possibility in patients presenting with EGPA\u2010like symptoms shortly after vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis characterized by tissue infiltration by eosinophils and hyper eosinophilia. We present a case of EGPA in a middle\u2010aged man following influenza vaccination. The patient developed respiratory symptoms, skin lesions, joint pain, and neurological deficits. Diagnostic tests revealed eosinophilia, positive anti\u2010neutrophil cytoplasmic antibodies, and elevated acute phase reactants. This report highlights a potential association between influenza vaccination and EGPA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8217","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T10:45:33Z","timestamp":1700909133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eosinophilic granulomatosis with polyangiitis following flu guard influenza vaccination: A case report"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3555-8908","authenticated-orcid":false,"given":"Mehdi","family":"Jafarpour","sequence":"first","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Daneshvar","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Taher","family":"Eftekharsadat","sequence":"additional","affiliation":[{"name":"Department of Pathology Imam Reza Hospital Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Khabbazi","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Pourbagherian","sequence":"additional","affiliation":[{"name":"Immunology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.627776"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9080815"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109061"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221794"},{"issue":"3","key":"e_1_2_12_6_1","first-page":"95","article-title":"Churg\u2010Strauss syndrome following vaccination against 2010 influenza a (H1N1): a case report","volume":"23","author":"Fu MH","year":"2014","journal-title":"Acta Neurol Taiwan"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10050716"},{"issue":"1","key":"e_1_2_12_8_1","article-title":"Eosinophilic granulomatosis with polyangiitis diagnosed in an elderly female after the second dose of mRNA vaccine against COVID\u201019","volume":"14","author":"Ibrahim H","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397113666170517155443"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202803"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12515-9"},{"key":"e_1_2_12_12_1","first-page":"471","volume-title":"Seminars in Respiratory and Critical Care Medicine","author":"Nguyen Y","year":"2018"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.624848"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00819-y"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:23:59Z","timestamp":1702445039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/ccr3.8217"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8217","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8217"}}