{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:36:06Z","timestamp":1764333366740,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:sec><jats:label\/><jats:p>The coronavirus disease 2019 (COVID\u201019) pandemic is responsible for huge morbidity and mortality throughout the world. Several serious complications of this disease have been reported. It can cause hypercoagulability, which may lead to venous and arterial thromboembolic diseases. This hypercoagulability state is also associated with high morbidity and mortality. Arterial thrombosis in COVID\u201019 is poorly described compared to venous thrombosis and pulmonary embolism. We report a case of an extensive arterial thrombosis leading to a limb ischemia with extremely high D\u2010dimer in a COVID\u201019 patient. A 69\u2010year\u2010old man was hospitalized for febrile dyspnea. He is a hypertensive and diabetic patient. On admission, pulse oxygen saturation was 72% on room air. He had cyanosis of the left foot up to the mid\u2010thigh. The left pedal, posterior tibial, popliteal and femoral pulses were abolished. Chest CT scan was in favor of COVID\u201019. He has a high D\u2010dimer level of 257,344\u2009ng\/mL. Arterial Echo\u2010Doppler found an extensive intraluminal thrombus along the arterial axes of the left lower limb, completely obstructing them, starting from the primitive iliac artery just after its bifurcation with the aorta, and extending distally (external iliac; common femoral; superficial femoral; popliteal; anterior tibial; posterior tibial; fibular and pedal). The patient was diagnosed with COVID\u201019 critical form, associated with ischemia of the left lower limb secondary to an extensive arterial thrombosis. He was receiving anticoagulation, and underwent surgical amputation of the ischemic limb. The patient survived the event; however, he was on long\u2010term oxygen therapy at home. Arterial thrombosis may occur during COVID\u201019 and may be responsible for peripheral or central ischemia aggravating morbidity and mortality. The occurrence of these events is related to the D\u2010dimer value. Anticoagulation is an important part of the management of COVID\u201019, especially in severe forms in order to limit the occurrence of these thromboembolic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8231","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:38:37Z","timestamp":1700570317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An extensive arterial thrombosis with lower limb ischemia in a <scp>COVID<\/scp>\u201019 patient: A case report"],"prefix":"10.1002","volume":"11","author":[{"given":"Johary Andriamamonjisoa","family":"Andriamizanaka","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine University of Antananarivo, Joseph Raseta Befelatanana University Hospital Antananarivo  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8613-7929","authenticated-orcid":false,"given":"Etienne","family":"Rakotomijoro","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine University of Antananarivo, Joseph Raseta Befelatanana University Hospital Antananarivo  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volatiana","family":"Andriananja","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine University of Antananarivo, Joseph Raseta Befelatanana University Hospital Antananarivo  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaja","family":"Raberahona","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine University of Antananarivo, Joseph Raseta Befelatanana University Hospital Antananarivo  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radonirina Lazasoa","family":"Andrianasolo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine University of Antananarivo, Joseph Raseta Befelatanana University Hospital Antananarivo  Antananarivo Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivonirina Andry","family":"Rakotoarivelo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine University of Fianarantsoa, University Hospital Tambohobe Fianarantsoa  Fianarantsoa Madagascar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"de Dieu\u00a0Randria\u00a0Mamy","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine University of Antananarivo, Joseph Raseta Befelatanana University Hospital Antananarivo  Antananarivo 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