{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:21:30Z","timestamp":1764645690737,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>It is important to consider WDLS as a potential cause of tongue lesions and include it in the list of differential diagnoses. When performing surgical intervention, it is crucial to remove enough tissue around the lesion, and regular follow\u2010up is necessary due to the high risk of recurrence, despite its rarity, when margins are positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Liposarcoma (LS) is the most common soft tissue sarcomas (STSs) that arise from embryonic mesenchymal tissue. Though these sarcomas commonly arise at retroperitoneal locations and extremities, the appearance of these tumors in the head and neck region is rare, with the tongue as a preferred site. As per WHO 2020, LS is classified into four subtypes based on morphology, namely, Well\u2010differentiated liposarcoma (WDLS), Dedifferentiated liposarcoma (DDLS), Myxoid liposarcoma (MLS), and Pleomorphic liposarcoma (PLS). WLS is the most common variant among all. Here, we had a case of 55\u2009years old male with the complaint of swelling in the left lateral border of the tongue with the preliminary diagnosis of pleomorphic adenoma. The patient underwent a left partial glossectomy with adequate margins. Further evaluation of the lesion revealed a clear cell tumor that was ultimately confirmed as liposarcoma on immunohistochemistry that showed tumor cells positive for S100, CDK4, and MDM2 with 2% Ki\u201067. Postsurgical status of the patient was evaluated by F18 FDG PET CTscan, which was normal. Currently, the patient is under regular follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8237","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T12:09:01Z","timestamp":1700654941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Well\u2010differentiated liposarcoma of tongue: A case report"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8647-3738","authenticated-orcid":false,"given":"Moushami","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nepal Cancer Hospital and Research Center  Lalitpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun R.","family":"Napit","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nepal Cancer Hospital and Research Center  Lalitpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunja","family":"Piya","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nepal Cancer Hospital and Research Center  Lalitpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhat Chandra","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology Nepal Cancer Hospital and Research Center  Lalitpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sambit","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Core Diagnostics National reference Lab  Gurugram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayali","family":"Shinde","sequence":"additional","affiliation":[{"name":"Core Diagnostics National reference Lab  Gurugram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekta","family":"Jain","sequence":"additional","affiliation":[{"name":"Core Diagnostics National reference Lab  Gurugram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari Prasad","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nepal Cancer Hospital and Research Center  Lalitpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"issue":"9","key":"e_1_2_11_2_1","first-page":"6233","article-title":"Current classification, treatment options, and new perspectives in the management of adipocytic sarcomas","volume":"11","author":"De Vita A","year":"2016","journal-title":"OncoTargetsTher"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0835-6"},{"key":"e_1_2_11_4_1","unstructured":"WHO classification.2022. 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Available from:https:\/\/www.pathologyoutlines.com\/topic\/softtissuewdliposarcoma.html"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"257","article-title":"Atypical lipomatous tumor of the tongue: report of a case","volume":"64","author":"Moritani N","year":"2010","journal-title":"Acta Med Okayama"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130608501117"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.01.006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0327-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00030-6"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-2-21"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.06.222"},{"key":"e_1_2_11_14_1","unstructured":"FletcherCDM BridgeJA PcwH MertensF.WHO Classification of Tumours of Soft Tissue and Bone.2013;5:32."}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:21:58Z","timestamp":1702444918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/ccr3.8237"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8237","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8237"}}