{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:05:10Z","timestamp":1787508310229,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>In the acute phase of Ebola virus disease (EVD) premature neonatal survival is extremely rare. High mortality is related to prematurity, neonatal complications of Ebola, and precarious conditions of neonatal care in underresourced ETUs. This is a case of preterm neonatal survival in the setting of acute maternal EVD infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>This case describes rare preterm newborn survival in the setting of an Ebola treatment unit in Eastern DRC. The neonate was born vaginally to an acutely ill 17\u2010year\u2010old mother who was vaccinated against Ebola virus after being identified as a contact of her father, who was a confirmed case and who did not survive his infection. This woman was admitted to an Ebola treatment unit at 32\u2009weeks of gestation and given monoclonal antibody treatment. She gave birth vaginally, succumbing to postpartum hemorrhage 14\u2009h after delivery. This child survived despite compounding vulnerabilities of preterm birth and maternal Ebola infection. Despite a negative test for EVD, the neonate was given a single dose of monoclonal antibody therapy in the first days of life. We believe maternal vaccination and neonatal monoclonal antibody treatment contributed to the child's survival. The circumstances surrounding neonatal survival in this extremely resource\u2010limited context must be analyzed and disseminated in order to increase rates of neonatal and maternal survival in future outbreaks. Maternal and neonatal health are critical aspects of outbreak response that have been understudied and underreported leaving clinicians severely underresourced to provide life\u2010saving care in outbreak settings. Pregnancy and childbirth do not stop in times of disease outbreak, adequate equipment and trained staff required for quality neonatal care must be considered in future outbreak responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8253","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T18:37:57Z","timestamp":1700851077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A premature newborn born to an adolescent girl with acute\n                    <scp>Ebola<\/scp>\n                    virus disease and malaria survives in a resource\u2010limited setting in an Ebola treatment unit in\n                    <scp>DR<\/scp>\n                    Congo: \u201cA case report\u201d"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-8388","authenticated-orcid":false,"given":"Prince","family":"Imani\u2010Musimwa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine University of Goma  Goma Democratic Republic of Congo"},{"name":"Centre Interdisciplinaire de Recherche et Promotion des Droits \u00e0 la Sant\u00e9 (CIRPRODS)  Bukavu Democratic Republic of Congo"},{"name":"School of Public Health University of Goma  Goma Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0074-7538","authenticated-orcid":false,"given":"Emilie","family":"Grant","sequence":"additional","affiliation":[{"name":"Center for Humanitarian Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheline","family":"Feza\u2010Malira","sequence":"additional","affiliation":[{"name":"International Medical Corps (IMC)  Goma Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-3570","authenticated-orcid":false,"given":"Placide","family":"Mbala\u2010Kingebeni","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Biomedicale (INRB)  Kinshasa Democratic Republic of Congo"},{"name":"Departement of Medical Biology, School of Medicine University of Kinshasa  Kinshasa Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gis\u00e8le","family":"Buhoro\u2010Baabo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, School of Medicine University of Goma  Goma Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-5762","authenticated-orcid":false,"given":"Esp\u00e9rence","family":"Zawadi\u2010Endanda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, School of Medicine University of Goma  Goma Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-0252","authenticated-orcid":false,"given":"Rigo","family":"Fraterne\u2010Muhayangabo","sequence":"additional","affiliation":[{"name":"School of Public Health University of Goma  Goma Democratic Republic of Congo"},{"name":"International Medical Corps (IMC)  Goma Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8165-2654","authenticated-orcid":false,"given":"In\u00e8s","family":"Claris\u2010Mwatsi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine University of Goma  Goma Democratic Republic of Congo"},{"name":"School of Public Health University of Goma  Goma Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zacharie","family":"Tsongo\u2010Kibendelwa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine University of Kisangani  Kisangani Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Nyakio\u2010Ngeleza","sequence":"additional","affiliation":[{"name":"Departement of Obstetrics and Gynecology, School of Medicine Official University Of Bukavu  Bukavu Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihali","family":"Juakali\u2010Kyolov","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine University of Kisangani  Kisangani Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis","family":"Wembonyama\u2010Okitosho","sequence":"additional","affiliation":[{"name":"School of Public Health University of Goma  Goma Democratic Republic of Congo"},{"name":"Department Pediatrics and Neonatology, School of Medicine University of Lumbumbashi  Lubumbashi Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-8159","authenticated-orcid":false,"given":"Dieudonn\u00e9","family":"Sengey\u2010Mushengezi\u2010Amani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine University of Kinshasa  Kinshasa Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-8704","authenticated-orcid":false,"given":"Daniel","family":"Mukadi\u2010Bamuleka","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Biomedicale (INRB)  Kinshasa Democratic Republic of Congo"},{"name":"Departement of Medical Biology, School of Medicine University of Kinshasa  Kinshasa Democratic Republic of Congo"},{"name":"Rodolphe M\u00e9rieux INRB\u2010Goma Laboratory  Goma Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7182-2998","authenticated-orcid":false,"given":"Mija","family":"Ververs","sequence":"additional","affiliation":[{"name":"Center for Humanitarian Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization.Ebola virus disease. Accessed November 12 2022.https:\/\/www.who.int\/health\u2010topics\/ebola#tab=tab_1"},{"key":"e_1_2_12_3_1","unstructured":"Democratic Republic of the Congo|ReliefWeb.DRC: 15th EVD Outbreak\u2010Emergency Plan of Action (EPoA) DREF n\u00b0 MDRCD038. Accessed October 8 2023.https:\/\/reliefweb.int\/report\/democratic\u2010republic\u2010congo\/drc\u201015th\u2010evd\u2010outbreak\u2010emergency\u2010plan\u2010action\u2010epoa\u2010dref\u2010ndeg\u2010mdrcd038"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001197"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.9745\/GHSP-D-19-00422"},{"key":"e_1_2_12_6_1","unstructured":"World Health Organization.Ebola virus disease\u2013Democratic Republic of the Congo. Accessed December 10 2022.https:\/\/www.who.int\/emergencies\/disease\u2010outbreak\u2010news\/item\/2022\u2010DON377"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/TJOG.TJOG_3_17"},{"key":"e_1_2_12_8_1","unstructured":"World Health Organization.Guidelines for the management of pregnant and breastfeeding women in the context of Ebola virus disease. Accessed October 8 2023.https:\/\/www.who.int\/publications\/i\/item\/9789240001381"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix290"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1584-6"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1910993"},{"key":"e_1_2_12_12_1","unstructured":"National Institutes of Health (NIH).Independent monitoring board recommends early termination of Ebola therapeutics trial in DRC because of favorable results with two of four candidates. Accessed October 8 2023.https:\/\/www.nih.gov\/news\u2010events\/news\u2010releases\/independent\u2010monitoring\u2010board\u2010recommends\u2010early\u2010termination\u2010ebola\u2010therapeutics\u2010trial\u2010drc\u2010because\u2010favorable\u2010results\u2010two\u2010four\u2010candidates"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000533"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/JP.2015.189"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/PATH.4456"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/985646"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw493"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30278-9"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:20:13Z","timestamp":1702426813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/ccr3.8253"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8253","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8253"}}