{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:38:00Z","timestamp":1783478280401,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Ectopic pituitary adenoma is a rare neoplasm located in the clivus and could mimic other clival tumors. Diagnosis and treatment could be challenging. It should be considered in the differential diagnosis of clival tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Ectopic pituitary adenomas (EPAs) are isolated adenomas that can be located in variable locations outside the sella turcica and have a normal\u2010appearing pituitary gland. These tumors are rare and are thought to often arise from embryological remnants along the route of Rathke's pouch migration. EPAs are associated with a wide range of clinical manifestations depending on hormonal activity and involvement of adjacent structures, which can represent a challenge in making the diagnosis and deciding on the most appropriate management. In this case study, we report a 47\u2010year\u2010old male who presented with visual disturbances, a headache, and generalized weakness. Magnetic resonance imaging showed a 2\u2009cm mass located in the clivus invading the sphenoid sinus with an intact pituitary gland. The patient underwent endoscopic transsphenoidal surgery to eradicate the mass while maintaining the integrity of the pituitary gland, which was successful and uneventful. Pathological studies were consistent with prolactinoma, with no cytological malignant features. Post\u2010surgery, symptoms notably improved, and serum prolactin levels significantly dropped, The patient's condition was satisfactory on follow\u2010up with no long\u2010term complications reported. This paper contributes to the existing literature by sharing the clinical management of a challenging and uncommon case.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8255","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T14:11:47Z","timestamp":1700575907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clival ectopic pituitary prolactinoma was successfully managed by transsphenoidal surgery: A rare case report"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-5733","authenticated-orcid":false,"given":"Marah","family":"Mansour","sequence":"first","affiliation":[{"name":"Faculty of Medicine Tartous University  Tartous Syria"},{"name":"Division of Colon and Rectal Surgery, Department of Surgery Mayo Clinic Hospital  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinah","family":"Khozamah","sequence":"additional","affiliation":[{"name":"Department of ENT Ibn Al\u2010Nafees Hospital  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmonem","family":"Naksho","sequence":"additional","affiliation":[{"name":"MSc Global Public Health Nutrition, School of Life Sciences University of Westminster  London UK"},{"name":"Doctor of Medicine, Faculty of Medicine AlBaath University  Homs Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roaa","family":"Zayat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Damascus  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaa","family":"Al\u00a0Sabbagh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Damascus  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Deeb","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tartous University  Tartous Syria"},{"name":"Department of ENT Al Basel Hospital  Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.34.538"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-019-00954-y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/76663418"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-020-01071-x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.10.200"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200203000-00035"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-012-0336-9"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.37.399"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01758-x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1592081"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2021.12.005"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usac182"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.02.118"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:19:48Z","timestamp":1702444788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/ccr3.8255"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8255","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8255"}}