{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:16:30Z","timestamp":1785147390015,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T00:00:00Z","timestamp":1700870400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Medication\u2010related osteonecrosis of the jaws (MRONJ) is a serious debilitating disease resulting from long\u2010term treatment with Antiresorptive drugs such as Bisphosphonates or Denosumab, which significantly affects patients' quality of life. A 43\u2010year\u2010old female patient with stage 4 breast cancer and treated with Zoledronic Acid for bone metastases was referred to the Department of Oral Medicine at the Faculty of Dentistry, Damascus University. The main complaint was pain in the right maxilla. Intraoral examination showed an exposure of necrotic bone in the right maxillary region with presence of purulent exudate. The treatment plan was discussed with the patient. Treatment included resection of all necrotic bone and application of Advanced platelet\u2010rich fibrin (A\u2010PRF) clots and membranes. Follow\u2010up and outcome were conducted by clinical measures to assess healing and recurrence (6\u2010month follow\u2010up). Topical treatment with A\u2010PRF demonstrated a reduction in pain and resulted in complete wound healing within 30\u2009days. A\u2010PRF stimulates the release of growth factors and chemotaxis involved in tissue repair mechanisms. This method seemed to be effective in the treatment of MRONJ.<\/jats:p>","DOI":"10.1002\/ccr3.8259","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T10:48:46Z","timestamp":1700909326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The use of advanced\u2010platelet rich fibrin (A\u2010PRF) in the management of medication\u2010related osteonecrosis of the jaw\u00a0(MRONJ): A case report"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1633-7210","authenticated-orcid":false,"given":"Maan Ahmad Rafik","family":"Asfour","sequence":"first","affiliation":[{"name":"Oral Medicine Department, Faculty of Dentistry Damascus University  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8606-3122","authenticated-orcid":false,"given":"Abeer Ahmad","family":"Aljoujou","sequence":"additional","affiliation":[{"name":"Oral Medicine Department, Faculty of Dentistry Damascus University  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-3186","authenticated-orcid":false,"given":"Maher Sadik","family":"Saifo","sequence":"additional","affiliation":[{"name":"Oncology Department\u2010 Medical Oncology, Faculty of Medicine Damascus University  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-4217","authenticated-orcid":false,"given":"Haya A. 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