{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:17:50Z","timestamp":1783113470784,"version":"3.54.6"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>Liver cysts are common benign lesions with rare malignancy potential. Distinguishing between benign and malignant tumors within liver cysts is challenging. We present the case of a patient with a chronically expanding hematoma within a liver cyst that was resected under suspicion of liver cystadenocarcinoma. A 73\u2010year\u2010old female patient presented with elevated hepatobiliary enzyme levels, no viral hepatitis, elevated tumor marker levels, and preserved liver capacity (Child\u2013Pugh grade A). Abdominal ultrasonography revealed a large cyst (&gt;10\u2009cm) occupying the right lobe and a 25\u2010mm mass lesion with mixed echogenicity inside the cyst. Contrast\u2010enhanced computed tomography showed atrophy of the parenchyma of the right lobe and dilation of the right intrahepatic bile duct due to the large cyst. Moreover, in the arterial phase, a point\u2010like high\u2010density area was observed inside the nodule, which increased from 25 to 35\u2009mm over 3\u2009months. Diffusion\u2010weighted magnetic resonance imaging revealed a high\u2010intensity signal within the nodule; however, positron emission tomography did not show an increased accumulation of fluorodeoxyglucose in the same area. Considering the risk of peritoneal dissemination if the cyst was punctured and found to be malignant, we performed a right hepatectomy. Pathological findings revealed a brownish fluid\u2010filled cyst containing a dark reddish nodule diffusely filled with hematoma, confirming the absence of a malignancy. To date, the patient has not experienced recurrence. We encountered a case of a chronic, expanding hematoma originating from a liver cyst that was difficult to distinguish preoperatively from a liver cystadenocarcinoma.<\/jats:p>","DOI":"10.1002\/ccr3.8294","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T22:29:46Z","timestamp":1701815386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resection of chronic expanding hematoma within the liver cyst difficult to differentiate from liver cystadenocarcinoma: A case report"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1138-7437","authenticated-orcid":false,"given":"Kodai","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Surgery Isehara Kyodo Hospital  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Surgery Isehara Kyodo Hospital  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Surgery Isehara Kyodo Hospital  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kigasawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Isehara Kyodo Hospital  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Surgery Isehara Kyodo Hospital  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihito","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Surgery Isehara Kyodo Hospital  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kabeshima","sequence":"additional","affiliation":[{"name":"Department of Surgery Isehara Kyodo Hospital  Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.08.014"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3616"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03310210043026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i23.3543"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i43.7603"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-022-01548-w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-023-01864-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01775-9"},{"key":"e_1_2_11_10_1","volume-title":"Tumor of the Liver and Intrahepatic Bile Ducts. Atlas of Tumor Pathology","author":"Ishak KG","year":"2001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4238\/2014.August.25.1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.04.023"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.8294","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:28:00Z","timestamp":1783110480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/ccr3.8294"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8294","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8294"}}