{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:18:52Z","timestamp":1783113532181,"version":"3.54.6"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical message<\/jats:title>\n                    <jats:p>Subcutaneous panniculitis\u2010like T\u2010cell lymphoma, a primary cutaneous lymphoma, which is described as following a slow course, could claim life. The occurrence of facial and breast nodules, the association with hemophagocytic lymphohistiocytosis, and the extent of necrosis and ulceration are signs of its aggressive nature needing early diagnosis and prompt treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) is a rare skin disease that accounts for &lt;1% of all peripheral T\u2010cell lymphomas. It is described as following a slow and gradual process. However, it can be associated with a variety of clinical symptoms ranging from mild to severe. Hemophagocytic lymphohistiocytosis (HLH), a rare and potentially fatal hematologic factor that complicates SPTCL in 20% of cases, is an important prognostic factor. We report here an aggressive case of disseminated SPTCL with HLH involving a young woman who presented with extensive necrosis and ulceration at diagnosis. The report highlights the aggressive course of the disease, the occurrence of facial and breast nodules, the association with HLH, and the extent of necrosis and ulceration. The report highlights the poor prognosis despite polychemotherapy regimen use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8342","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T22:54:53Z","timestamp":1709679293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An unusual presentation of subcutaneous panniculitis\u2010like T\u2010cell lymphoma: Extensive necrosis and hemophagocytic lymphohistiocytosis: A case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0338-2756","authenticated-orcid":false,"given":"Mehdi","family":"Loukhnati","sequence":"first","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Mohammed VI University Hospital Cadi Ayyad University  Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4099-7947","authenticated-orcid":false,"given":"Khaoula","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Mohammed VI University Hospital Cadi Ayyad University  Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Ezzahra","family":"Lahlimi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Mohammed VI University Hospital Cadi Ayyad University  Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illias","family":"Tazi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Mohammed VI University Hospital Cadi Ayyad University  Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"issue":"13","key":"e_1_2_11_3_1","first-page":"1058","article-title":"HAVCR2 mutations are associated with severe hemophagocytic syndrome in subcutaneous panniculitis\u2010like T\u2010cell lymphoma","volume":"135","author":"Sonigo G","year":"2020","journal-title":"Blood"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199101000-00002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2543"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2008.05.008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.25251\/skin.3.2.42"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20502"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181a84f32"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000187933.87103.03"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00493.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001434"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.650822"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13863"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.8342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:41:24Z","timestamp":1783111284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ccr3.8342"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8342","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2022-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8342"}}