{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:21:25Z","timestamp":1789662085973,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>Valproic acid (VPA) is a wide\u2010ranging anti\u2010epileptic medication that primarily affects bipolar disorder, mania, and migraine. The leading causes of mortality associated with acute poisoning from VPA are nervous system toxicity, drug\u2010induced shock due to encephalopathy from hyperammonemia, as well as acute liver and kidney failure, and respiratory depression that contribute to hemodynamic instability. Treatment of acute VPA poisoning primarily involves in\u00a0vitro elimination methods, including hemoperfusion (HP), hemodialysis, and hemofiltration, as well as drug remedies such as L\u2010carnitine and meropenem. Nonetheless, there are conflicting opinions regarding drug usage. This article details the three cases of acute poisoning from VPA. The fundamental approach to treatment employs HP assisted by blood concentration monitoring to alleviate shock and stabilize hemodynamics. This investigation presents guidance for the treatment and management of acute poisoning with VPA in clinical settings.<\/jats:p>","DOI":"10.1002\/ccr3.8367","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T02:49:49Z","timestamp":1703731789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Rescue strategies for valproic acid overdose poisoning: Case series and literature review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-4607","authenticated-orcid":false,"given":"Renzhu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Xiangtan Central Hospital  Xiangtan China"},{"name":"Zhou Honghao Research Institute Xiangtan Xiangtan Central Hospital  Xiangtan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Children Health Care Xiangtan Maternal and Child Care Service Centre  Xiangtan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Xiangtan Central Hospital  Xiangtan China"},{"name":"Zhou Honghao Research Institute Xiangtan Xiangtan Central Hospital  Xiangtan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Xiangtan Central Hospital  Xiangtan China"},{"name":"Zhou Honghao Research Institute Xiangtan Xiangtan Central Hospital  Xiangtan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Xiangtan Central Hospital  Xiangtan China"},{"name":"Zhou Honghao Research Institute Xiangtan Xiangtan Central Hospital  Xiangtan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X17666181227165722"},{"issue":"6","key":"e_1_2_10_3_1","first-page":"1683","article-title":"Status epilepticus, refractory status epilepticus, and super\u2010refractory status epilepticus","volume":"24","author":"Nelson SE","year":"2018","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2021.1931126"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.13135"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2022.20.4.747"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3402067"},{"issue":"1","key":"e_1_2_10_8_1","article-title":"Consensus guidelines for therapeutic drug monitoring in Neuropsychopharmacology: update 2017","volume":"51","author":"Hiemke C","year":"2018","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2022.12.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1035441"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2022.07.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.09.033"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181c13a30"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199005010-00006"},{"issue":"1","key":"e_1_2_10_15_1","first-page":"7","article-title":"Comparing the toxicity of valproate sodium with divalproex sodium","volume":"9","author":"Feng\u2010jiao H","year":"2012","journal-title":"Chin J Pharmacovigil"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000546"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650701846262"},{"key":"e_1_2_10_18_1","unstructured":"U.S. Food and Drug Administration.Valproic acid [EB\/OL]. 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