{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:31:02Z","timestamp":1781566262902,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Posterior reversible encephalopathy syndrome may occur secondary to abrupt cessation of antihypertensive therapy. A gradual reduction in blood pressure and counseling regarding medication adherence are crucial to prevent adverse consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Posterior reversible encephalopathy syndrome (PRES) is a reversible clinical radiographic syndrome with headache, hypertensive encephalopathy, seizures, and visual disturbances as common modes of presentation. PRES can be attributed to several risk factors. We reported the case of a 66\u2010year\u2010old Asian female with PRES following nonadherence to antihypertensive treatment. Initially, her computed tomography scan of the head was normal. After 48\u2009h, we again ordered a head CT scan, which showed lesions suggestive of hypertensive encephalopathy. We immediately reduced 20%\u201325% of mean arterial pressure, followed by a gradual blood pressure lowering to avoid adverse consequences. We did a follow\u2010up CT scan of the head at 2\u2009weeks, showing the resolution of early lesions. Hence, we made a diagnosis of PRES. In these patients, it is crucial to ensure medication adherence to avoid complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8393","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T07:56:12Z","timestamp":1704268572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Posterior reversible encephalopathy syndrome due to nonadherence to antihypertensive treatment: A case report from Nepal"],"prefix":"10.1002","volume":"12","author":[{"given":"K.C.","family":"Priyanka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B. P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-4636","authenticated-orcid":false,"given":"Ayush","family":"Anand","sequence":"additional","affiliation":[{"name":"B. P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5679-8088","authenticated-orcid":false,"given":"Salman Haidar","family":"Husain","sequence":"additional","affiliation":[{"name":"B. P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5895-1405","authenticated-orcid":false,"given":"Urza","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B. P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8392-8028","authenticated-orcid":false,"given":"Sanjib Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B. P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340803"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0590"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00111-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc052954"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0549"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.159.2.1632361"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2005.00520.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001405"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2020-137706"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.02.013"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02143-6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omx011"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(74)91639-0"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026582"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T03:55:05Z","timestamp":1706846105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/ccr3.8393"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8393","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8393"}}