{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:49:55Z","timestamp":1785289795991,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Prostate cancer is one of the two most common non\u2010cutaneous cancers in men. Its presentation might be with unusual symptoms and cause the wrong initial diagnosis. This case report discusses a rare neurologic manifestation of advanced metastatic cancer in a low\u2010risk man. He had been receiving treatment for multiple sclerosis incorrectly due to unusual manifestations such as claudication and pelvic, leg, and shoulder pain. The patient underwent a whole\u2010body bone scan and then a transrectal ultrasound\u2010guided biopsy, which confirmed metastatic prostate cancer with a Gleason score between 7\/10 and 10\/10 in all samples. Following treatment with chemotherapeutic injections (docetaxel), luteinizing hormone\u2010releasing hormone (LHRH) analogous (Zoladex), and testosterone\u2010suppressing tablets (abiraterone), the disease has been under control and prostate\u2010specific antigen (PSA) level has decreased significantly. The most common sites of metastasis are regional lymph nodes, bones, and lungs. However, there are reports about the spread of this type of cancer to other parts of the body. Although most patients are diagnosed when the tumor is localized to the prostate, in about 25% of patients, the disease is diagnosed when metastasis has occurred. Some markers can assist physicians in the diagnosis of this disease, such as the Prostate Health Index and the 4\u2009K score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>The diagnosis of prostate cancer should be considered in all age ranges of adult men. The long\u2010distance metastasis might cause unusual presentations of the disease, such as neurologic, musculoskeletal, and dermatologic symptoms and signs far from the origin of the cancer, before genitourinary manifestations. It is crucial to keep the diagnosis of prostate cancer in mind for men with suggestive signs and symptoms that are not usually detected in this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8447","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T22:29:56Z","timestamp":1706480996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An unusual presentation of metastatic prostate cancer in a 44\u2010year\u2010old man: A case report and review of the literature"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8612-0571","authenticated-orcid":false,"given":"Homa","family":"Taheri","sequence":"first","affiliation":[{"name":"Cedars\u2010Sinai Cardiology Department  Beverly Hills California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3694-6863","authenticated-orcid":false,"given":"Pouya","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8598-7996","authenticated-orcid":false,"given":"Pedram","family":"Nazari","sequence":"additional","affiliation":[{"name":"Cancer Research Center Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0616-8870","authenticated-orcid":false,"given":"Amirhosein","family":"Kefayat","sequence":"additional","affiliation":[{"name":"Oncology Department Isfahan University of Medical Sciences  Isfahan 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