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Hemolytic anemia could continue for a relatively long time in elder patient with G6PD deficiency, which might be related to other adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Aspirin\u2010related hemolysis in G6PD\u2010deficient individuals was generally reported among patients who received high\u2010dose supplements within several days after ingestion. The safety of long\u2010term and low\u2010dose (50\u2013325\u2009mg\/day) aspirin in patients coexist G6PD deficiency and cardiovascular disease is neglected in clinical practice. In this case, we observed a late\u2010onset hemolysis and subsequent fatal subdural hemorrhage in one G6PD\u2010deficient individual who had received long\u2010term and low\u2010dose aspirin. An 83\u2010year\u2010old male was diagnosed with acute ischemic stroke and treated with 100 mg\/day aspirin at the emergency room. After admission, the patient was diagnosed with severe G6PD deficiency based on enzyme activity, but no hemolysis occurred within 10\u2010day aspirin therapy in the hospital. Hence, 100 mg\/day aspirin was continued on discharge. Two months later, the patient presented acute hemolysis manifested as fatigue, dark urine, and moderate jaundice. Although hemolysis was self\u2010limit in a few days, hemoglobin decline continued for 20\u2009days until a fatal subdural hemorrhage occurred. Our study indicated aspirin\u2010related hemolysis could be late\u2010onset in G6PD\u2010deficient individual even receiving low\u2010dose treatment and is probably linked to subsequent major bleeding events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8450","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T06:35:31Z","timestamp":1706596531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Late\u2010onset aspirin\u2010related hemolysis and subsequent subdural hemorrhage in patient with glucose\u20106\u2010phosphate dehydrogenase deficiency"],"prefix":"10.1002","volume":"12","author":[{"given":"Jianle","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology, Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology Meizhou people's Hospital  Meizhou 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