{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:25:21Z","timestamp":1783113921357,"version":"3.54.6"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>In the evaluation of acute flaccid paralysis, particularly in pediatric populations within endemic areas for schistosomiasis infection, clinicians must maintain a high index of suspicion for neuroschistosomiasis. Prompt identification is imperative to mitigate the risk of irreversible neurological sequelae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Spinal cord involvement in neuroschistosomiasis (NS) is considerably rare, with even fewer reported cases affecting the conus medullaris in children. While NS's neurological sequelae are typically thought to be reversible, delayed diagnosis and treatment can lead to permanent deficits. We report a case of a 9\u2010year\u2010old boy who presented with 3\u2009weeks of progressive bilateral lower extremity weakness. A spinal MRI showed patchy gadolinium enhancement in an expanded conus medullaris, leading to a presumed diagnosis of Guillain\u2013Barre syndrome, and the patient was treated with intravenous immunoglobulin. However, the lack of improvement necessitated surgical laminectomy. The post\u2010operative histopathological examination confirmed the presence of a schistosomal parasite. Despite initiating therapy with corticosteroid and praziquantel, the patient did not exhibit clinical improvement, resulting in persistent flaccid paralysis, bladder, and bowel incontinence. In conclusion, spinal NS should be considered in patients presenting with myeloradicular symptoms in regions endemic for schistosomal infection, as delayed recognition can result in irreversible outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8475","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T21:19:02Z","timestamp":1707427142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Conus medullaris neuroschistosomiasis mimicking Guillain\u2013Barre syndrome: A case of delayed diagnosis leading to permanent neurological damage"],"prefix":"10.1002","volume":"12","author":[{"given":"Nabil","family":"Aljuma'ai","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ibb University  Ibb Yemen"},{"name":"Department of Pediatrics Pediatric Consultation Clinic  Ibb Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-0890","authenticated-orcid":false,"given":"Saif A.","family":"Ghabisha","sequence":"additional","affiliation":[{"name":"Department of General Surgery Ibb University  Ibb Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7188-2715","authenticated-orcid":false,"given":"Faisal","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Urology Ibb University  Ibb Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha","family":"Al\u2010Mwald","sequence":"additional","affiliation":[{"name":"Department of Radiology Ibb University  Ibb Yemen"},{"name":"Radiology Yemen Scan Center  Ibb Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullatif","family":"Almohtadi","sequence":"additional","affiliation":[{"name":"Department of Radiology Ibb University  Ibb Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-6329","authenticated-orcid":false,"given":"Mohamed","family":"Badheeb","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hadhramaut University  Hadhramaut Yemen"},{"name":"Department of Internal Medicine, Yale New Haven Health Bridgeport Hospital  Bridgeport Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsc.2022.102388"},{"issue":"5","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.15537\/1658-3175.4341","article-title":"Acute toxemic schistosomiasis complicated by acute flaccid paraplegia due to schistosomal myeloradiculopathy in Sudan","volume":"29","author":"Ahmed AF","year":"2008","journal-title":"Saudi Med J"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2021.11.018"},{"issue":"7","key":"e_1_2_12_5_1","article-title":"Pediatric spinal neuroschistosomiasis in Yemen: an overlooked dilemma in an endemic region","volume":"15","author":"Aljuma'ai N","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-022-05696-0"},{"key":"e_1_2_12_7_1","article-title":"Spinal cord schistosomiasis: a child's case with an unsatisfactory outcome that mimicked an intramedullary neoplasm. A rare case report","volume":"82","author":"Mohamed AA","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443787"},{"issue":"5","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1212\/CON.0000000000000646","article-title":"Helminthic infections of the central nervous system","volume":"24","author":"Cho TA","year":"2018","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.4.1023"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8879121"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10235521"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762004000900010"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822004000300013"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.04.007"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_47_2023"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(73)90004-7"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70170-3"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.8475","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:00:20Z","timestamp":1783112420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/ccr3.8475"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8475","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8475"}}