{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:42:31Z","timestamp":1789422151274,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Key clinical message<\/jats:title>\n                    <jats:p>In in\u00a0vitro fertilization (IVF), laser offers several advantages. In this study, we employed laser to eliminate the zona pellucida of a contaminated embryo. This approach helps to rescue embryo with bacterial contamination, and improve embryo\u2010endometrium interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>To present a case report on the removal of a contaminated zona pellucida from an embryo of patient with a history of recurrent implantation failure (RIF), which was followed by a successful live birth. We present the case of a 34\u2010year\u2010old patient with a history of 3\u2009years of infertility who underwent in\u00a0vitro fertilization. During the culture process, the embryos became contaminated, leading to three failed implantations. Despite the aneuploidy of the embryo and the implementation of a washing technique, the contamination persisted. In the final attempt, the contaminated zona pellucida was successfully removed using laser, followed by embryo transfer, resulting in a live birth. We provided detailed clinical information, including patient demographics, infertility history, ovarian response, evidence of bacterial contamination, embryo development, treatment protocols, and outcomes. Laser excision of the zona pellucida is a safe and effective method for addressing bacterial infection in embryos.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8483","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:15:11Z","timestamp":1708474511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Zona pellucida removal resulted in a successful live birth: Report on a case with recurrent implantation failure due to embryonic bacteria contamination"],"prefix":"10.1002","volume":"12","author":[{"given":"Son Truong","family":"Dang","sequence":"first","affiliation":[{"name":"HP Fertility Hai Phong International Hospital of Obstetrics and Pediatrics  Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-5208","authenticated-orcid":false,"given":"Huy Phuong","family":"Tran","sequence":"additional","affiliation":[{"name":"Infertility Department Hung Vuong Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuong Nguyen","family":"Ho","sequence":"additional","affiliation":[{"name":"Taipei Fertility Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loc Thai","family":"Ly","sequence":"additional","affiliation":[{"name":"Infertility Department Hung Vuong Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuyet Thi\u2010Diem","family":"Hoang","sequence":"additional","affiliation":[{"name":"Infertility Department Hung Vuong Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang Nguyen\u2010Khanh","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Pham Ngoc Thach University of Medicine  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Tuan","family":"Do","sequence":"additional","affiliation":[{"name":"HP Fertility Hai Phong International Hospital of Obstetrics and Pediatrics  Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuan Duc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"HP Fertility Hai Phong International Hospital of Obstetrics and Pediatrics  Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Thi","family":"Dao","sequence":"additional","affiliation":[{"name":"HP Fertility Hai Phong International Hospital of Obstetrics and Pediatrics  Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem165"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01640-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0776-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2022.05.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.10.033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01773-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31228"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137417"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800027200"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2741\/3185"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00260-7"}],"container-title":["Clinical 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