{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:33:26Z","timestamp":1788435206251,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Congenital myotonic dystrophy should be considered in hypotonic infants with polyhydramniotic mothers with a positive history of myotonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Congenital myotonic dystrophy (CDM) is a predominantly maternally inherited disease and results from increased numbers of cytosine, thymine, and guanine (CTG) repeats in the unstable DNA regions and presents as hypotonia in the neonatal period and myotonia in adulthood. This report aims to present two cases of CDM. A first\u2010cousin couple was born and hospitalized due to hypotonia at birth and a maternal history of polyhydramnios during this pregnancy. The first\u2010born baby girl was admitted to the NICU with tachypnea and hypotonia, clubfoot, and frog\u2010like posture. The pregnancy was complicated by polyhydramnios. Interestingly, her first cousin was born the next day with a similar picture and history. Myotonia was detected in their mothers. The concurrent presence of hypotonia and polyhydramnios as well as maternal myotonia in a first cousin should be considered CDM until proven otherwise and this was confirmed by the EMG\u2010 NCV test.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8503","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T22:49:02Z","timestamp":1707346142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A couple of the first cousins born with hypotonia and maternal polyhydramnios"],"prefix":"10.1002","volume":"12","author":[{"given":"Mousa","family":"Ahmadpour\u2010kacho","sequence":"first","affiliation":[{"name":"Non\u2010Communicable Pediatric Diseases Research Center, Department of Pediatrics Babol University of Medical Sciences  Babol Iran"},{"name":"Non\u2010Communicable Pediatric Diseases Research Center, Department of Pediatrics Clinical Research Development Unit of Rouhani Hospital Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadollah Zahed","family":"Pasha","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Pediatric Diseases Research Center, Department of Pediatrics Babol University of Medical Sciences  Babol Iran"},{"name":"Non\u2010Communicable Pediatric Diseases Research Center, Department of Pediatrics Clinical Research Development Unit of Rouhani Hospital Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-8694","authenticated-orcid":false,"given":"Samira","family":"Pournajaf","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Pediatric Diseases Research Center, Department of Pediatrics Babol University of Medical Sciences  Babol Iran"},{"name":"Non\u2010Communicable Pediatric Diseases Research Center, Department of Pediatrics Clinical Research Development Unit of Rouhani Hospital Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"A Service of the National Library of Medicine","author":"Bookshelf 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