{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:24:03Z","timestamp":1783113843201,"version":"3.54.6"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sporadic thyrotoxic periodic paralysis (TPP) is a rare muscle disorder that manifests with abrupt muscle weakness and hypokalemia associated with hyperthyroidism. It is mostly reported in the Asian population, and rare in Caucasians. Only few cases have been reported in people with black ancestry. Here, we report a rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian. A 17\u2010year\u2010old man was admitted in the Neurology clinic with rapid proximal tetraplegia that started after strenuous physical activities at the school. Clinical examination confirmed the proximal weakness. In addition, he had bilateral ptosis, exophthalmia, and horizontal ophthalmoplegia. Laboratory testing showed normal serum potassium and creatinine, low calcium and TSH levels. However, CK, FT4, thyroid stimulating hormone antibody, and acetylcholine receptor antibody levels were high. In addition, electrocardiogram was normal while thyroid Doppler\u2010ultrasound showed heterogeneous, hypoechogenic, hypertrophic, and hyper vascularized gland. Patient had completely recovered his limb weakness within the following hours with symptomatic treatment. The clinical findings were consistent with Graves' disease, and he was put on Neomercazole. He did not present another episode of paralysis after 4\u2010years of follow up. This is a first case of thyrotoxic periodic paralysis reported in Mali and one of the rare cases in sub\u2010Saharan Africa. Despite its scarcity, all patients with acute weakness consecutive to effort, whether recurring or not, should be screened for TPP.<\/jats:p>","DOI":"10.1002\/ccr3.8527","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:37:25Z","timestamp":1708648645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A rare case of thyrotoxic periodic paralysis revealing Graves' disease in a young Malian"],"prefix":"10.1002","volume":"12","author":[{"given":"Mohamed Emile","family":"Demb\u00e9l\u00e9","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine et d'Odontostomatologie Universit\u00e9 des sciences, des techniques et des technologies de Bamako  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4279-7380","authenticated-orcid":false,"given":"Abdoulaye","family":"Yalcouy\u00e9","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine et d'Odontostomatologie Universit\u00e9 des sciences, des techniques et des technologies de Bamako  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Cissoko","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, CHU Point G  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6574-0956","authenticated-orcid":false,"given":"Lassana","family":"Ciss\u00e9","sequence":"additional","affiliation":[{"name":"Service de Neurologie, CHU Point G  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheick Oumar","family":"Guinto","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine et d'Odontostomatologie Universit\u00e9 des sciences, des techniques et des technologies de Bamako  Bamako Mali"},{"name":"Service de Neurologie, CHU Point G  Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guida","family":"Landour\u00e9","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine et d'Odontostomatologie Universit\u00e9 des sciences, des techniques et des technologies de Bamako  Bamako Mali"},{"name":"Service de Neurologie, CHU Point G  Bamako Mali"},{"name":"Neurogenetics Branch, NINDS, NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"95","article-title":"Thyrotoxic periodic paralysis: clinical challenges","volume":"64","author":"Vijayakumar A","year":"2014","journal-title":"J Thyroid Res"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2004.418"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc1110051"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3558"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(98)00122-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013256"},{"key":"e_1_2_11_8_1","first-page":"207","article-title":"Thyrotoxic hypokalemic periodic paralysis in two African black women","volume":"37","author":"Sow M","year":"2020","journal-title":"Pan Afr Med J"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(00)80010-7"},{"key":"e_1_2_11_10_1","article-title":"A literature review on thyrotoxic periodic paralysis","volume":"12","author":"Iqbal QZ","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2013.03.004"},{"key":"e_1_2_11_12_1","first-page":"315","article-title":"Thyrotoxic periodic paralysis: an unusual presentation of hyperthyroidism","volume":"75","author":"Salih M","year":"2017","journal-title":"Neth J Med"},{"key":"e_1_2_11_13_1","first-page":"148","article-title":"Clinical conferences at the Johns Hopkins Hospital. Hypokalemic periodic paralysis","volume":"143","author":"Charness ME","year":"1978","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200608000-00012"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-199509000-00008"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.8527","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:59:30Z","timestamp":1783112370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/ccr3.8527"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8527","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8527"}}