{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:20:57Z","timestamp":1783113657075,"version":"3.54.6"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>A thirty\u2010eight year\u2010old male presented with a seven\u2010week history of persistent fever accompanied by recurrent night sweats, chills, arthralgias, headache, and chest tightness.Initial laboratory testing showed non\u2010specific elevation of inflammatory markers, but was otherwise unremarkable.A palmar rash developed one week later, prompting testing for syphilis. Fluorescent treponemal antibody absorption (FTA\u2010ABS) and rapid plasma reagin (RPR) tests were both positive.Penicillin G was administered and the patient recovered uneventfully.Our case emphasizes the need for increased syphilis screening to ensure proper diagnosis and prompt treatment.<\/jats:p>","DOI":"10.1002\/ccr3.8583","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T22:55:08Z","timestamp":1709938508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secondary syphilis presenting as fever of unknown origin"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8771-2390","authenticated-orcid":false,"given":"Hannah Eloise","family":"Wilding","sequence":"first","affiliation":[{"name":"Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Hays","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Approach to the Adult with Fever of Unknown Origin","author":"Bor D","year":"2022"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"137","article-title":"Fever of unknown origin in adults","volume":"105","author":"David A","year":"2022","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.73"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39085.518148.BE"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178633719883282"},{"key":"e_1_2_10_7_1","unstructured":"U.S. Department of Health and Human Services.Screening Recommendations and Considerations Referenced in Treatment Guidelines and Original Sources. 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