{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:07:02Z","timestamp":1784657222677,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>Although the etiology of blue toe syndrome is varied, the association between blue toe syndrome and iron deficiency\u2010induced thrombocytosis (IDIT) has not been well established. We report the case of a 38\u2010year\u2010old Saudi male who presented with blue toe syndrome and laboratory investigations revealed severe thrombocytosis secondary to iron deficiency. The patient was managed with analgesics, antiplatelets, anticoagulation, intravenous fluids, and iron supplementation. Subsequently, his symptoms resolved within a few days. IDIT is crucial to consider as a possible cause of microvascular thrombosis disorders, especially in patients with severe thrombocytosis.<\/jats:p>","DOI":"10.1002\/ccr3.8596","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T06:53:58Z","timestamp":1712127238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Iron d\n                    <scp>eficiency\u2010induced<\/scp>\n                    thrombocytosis presenting with blue toe syndrome"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1448-2381","authenticated-orcid":false,"given":"Khaled","family":"Aboujabal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Sadek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3927-8440","authenticated-orcid":false,"given":"Koutaibah","family":"Obaid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisher","family":"Sawaf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmukhtar","family":"Habas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-2883","authenticated-orcid":false,"given":"Mhd Baraa","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-815944"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/536062"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.038"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.214312"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0416-1"},{"issue":"2","key":"e_1_2_12_7_1","article-title":"A rare case of recurrent arterial thrombosis secondary to iron deficiency anemia","volume":"14","author":"Aslam H","year":"2022","journal-title":"Cureus"},{"issue":"3","key":"e_1_2_12_8_1","article-title":"Iron deficiency anemia as a rare risk factor for recurrent pulmonary embolism and deep vein thrombosis","volume":"13","author":"Ezeh E","year":"2021","journal-title":"Cureus"},{"issue":"3","key":"e_1_2_12_9_1","article-title":"Iron\u2010deficiency anemia causes an ischemic stroke in a young man","volume":"11","author":"Fluss R","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8647126"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2715-x"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:27:49Z","timestamp":1764253669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ccr3.8596"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8596","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8596"}}