{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:20:15Z","timestamp":1783113615286,"version":"3.54.6"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>Neuroendocrine tumors (NETs) are a group of uncommon neoplasms derived from enterochromaffin or Kulchitsky cells (that secrete serotonin or other molecules into the bloodstream), which can manifest with symptoms of hormonal overproduction, namely carcinoid syndrome (CS). This can be the presenting feature in patients with advanced disease. We report the case of a 66\u2010year\u2010old woman presenting with chronic diarrhea, facial venous telangiectasia and elevated urinary 5\u2010hydrocyindoleacetic acid levels. A 68\u2010Ga DOTATOC PET\/CT scan revealed an ileal mass and lesions consistent with liver, ovary and bone metastasis. A liver biopsy confirmed the diagnosis of well\u2010differentiated NET G1. Therapy with somatostatin analogs achieved symptom control, but the liver disease progressed and the patient passed away after 2\u2009years of follow\u2010up. The challenge of diagnosing CS resides in its heterogeneous manifestations, which may range from mild to life\u2010threatening conditions. In this case, the cutaneous findings of venous telangiectasia strongly pointed to the correct diagnosis. Treatment can also be difficult due to refractory symptoms and inevitable progression of disease, highlighting the importance of early detection and thorough disease staging.<\/jats:p>","DOI":"10.1002\/ccr3.8641","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T06:26:10Z","timestamp":1709792770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The skin as a window to the gut: A case of carcinoid syndrome"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-1741","authenticated-orcid":false,"given":"Catarina Alves","family":"Costa","sequence":"first","affiliation":[{"name":"Internal Medicine Department Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (CHUdSA), Porto, Largo Professor Abel Salazar  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia","family":"Lopes","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (CHUdSA), Porto, Largo Professor Abel Salazar  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Patr\u00edcia","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Service, Pathology Department Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (CHUdSA), Porto, Largo Professor Abel Salazar  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno Jorge","family":"Lamas","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Service, Pathology Department Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (CHUdSA), Porto, Largo Professor Abel Salazar  Porto Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine University of Minho  Braga Portugal"},{"name":"ICVS\/3B's, PT Government Associate Laboratory University of Minho  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Cruz","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (CHUdSA), Porto, Largo Professor Abel Salazar  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000376"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2018\/e490s"},{"issue":"3","key":"e_1_2_11_4_1","article-title":"Carcinoid syndrome: a review","volume":"12","author":"Gade AK","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-019-0671-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2021.101304"},{"key":"e_1_2_11_7_1","first-page":"1","article-title":"What is the carcinoid syndrome? A critical appraisal of its proposed mediators","volume":"00","author":"Mulders M","year":"2023","journal-title":"Endocr Rev"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.191197"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2000-0001"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.8641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:40:14Z","timestamp":1783111214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ccr3.8641"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8641","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8641"}}