{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:31:48Z","timestamp":1764253908786,"version":"3.46.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>Extramedullary involvement of the central nervous system (CNS) in Chronic Myeloid Leukemia (CML) is an uncommon relapse. In this case, we present a unique instance of a 43\u2010year\u2010old male diagnosed with CML experiencing a CNS blast crisis.<\/jats:p>","DOI":"10.1002\/ccr3.8671","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T23:49:37Z","timestamp":1711496977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A chronic myeloid leukemia present with an unusual relapse in central nervous system: A case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-2921","authenticated-orcid":false,"given":"Mais","family":"Musleh","sequence":"first","affiliation":[{"name":"Department of Hematology, Faculty of Medicine Al Assad University Hospital  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qossay","family":"Alhussien","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine Al\u2010Mouwasat University Hospital  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(03)00528-1"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.5.11.3116-3123.1985"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907153410306"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90754-6"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30492-1"},{"key":"e_1_2_13_7_1","first-page":"808","article-title":"Leukemic synovitis as a presentation of myelomonocytic blast crisis of chronic myeloid leukemia","volume":"22","author":"Al\u2010Rayes HM","year":"2001","journal-title":"Saudi Med J"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21795"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.02.024"},{"key":"e_1_2_13_10_1","first-page":"150","article-title":"Pathological fracture as a manifestation of extramedullary blastic crisis in chronic myelogenous leukemia: report of one case","volume":"47","author":"Yu HH","year":"2006","journal-title":"Acta Paediatr Taiwan"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.737"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-011-0055-5"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.5608"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0829-4"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3059"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.01947.x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8588(05)70203-3"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0259"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-140665"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002315"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1586\/erp.09.1"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:27:51Z","timestamp":1764253671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ccr3.8671"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8671","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2024,3,26]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8671"}}