{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:30:26Z","timestamp":1764253826825,"version":"3.46.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eptifibatide, a GPIIb\/IIIa receptor inhibitor, has shown its efficacy and safety in patients with high clot burden in their coronary vessels. It is widely used in patients with this condition. However, this medication use is accompanied by complications in some cases. Thrombocytopenia which is a relatively common condition in patients admitted to the hospital, especially in the acute setting, can be caused by medications. This condition can occur as an antibody or non\u2010antibody\u2010mediated process, caused by medications, such as heparin, clopidogrel, and eptifibatide. In this case, we present a woman with acute coronary syndrome and a complex lesion with a clot in her coronary vessel who was treated with eptifibatide. It led to asymptomatic thrombocytopenia. Once detected in laboratory data, the infusion was held, and the platelet count recovered in less than 5\u2009days without additional treatment for this adverse effect. Eptifibatide is a medication used to treat acute coronary syndrome patients with a large thrombus in their coronary vessels. The mechanism of inducing thrombocytopenia by eptifibatide has not been proven yet, but it might be related to IgG antibodies. The severity of the disease can vary significantly, and the treatment is based on this factor. However, the main pillar of the treatment is the cessation of eptifibatide as soon as possible. This case draws the attention of physicians to one of the infrequent adverse effects of a commonly used medication in cardiology patients. Thrombocytopenia and its manifestations should be investigated and considered in patients who receive eptifibatide.<\/jats:p>","DOI":"10.1002\/ccr3.8694","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T05:07:36Z","timestamp":1711602456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A woman with eptifibatide (integrilin)\u2010induced thrombocytopenia following treatment of a clot in her coronary artery: A case report and literature review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9326-3253","authenticated-orcid":false,"given":"Morteza","family":"Safi","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center Shahid Beheshti University of Medical Sciences, Modarres Hospital  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1588-2812","authenticated-orcid":false,"given":"Roozbeh","family":"Nazari","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shahid Beheshti University of Medical Sciences, Modarres Hospital  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7142-8230","authenticated-orcid":false,"given":"Nahid","family":"Senobari","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shahid Beheshti University of Medical Sciences, Modarres Hospital  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8612-0571","authenticated-orcid":false,"given":"Homa","family":"Taheri","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Cardiology Department  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3694-6863","authenticated-orcid":false,"given":"Pouya","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Tehran Heart Center Cardiovascular Disease Research Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2468"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.22.2892"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12253"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ancard.2023.101609"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxad271"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijccm.IJCCM_279_17"},{"key":"e_1_2_11_8_1","first-page":"65","article-title":"The role of thrombocytopenia as an independent predictor of cardiovascular and renal damage in patients with systemic lupus erythematosus","volume":"77","author":"Salah M","year":"2009","journal-title":"Med J Cairo 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