{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:31:48Z","timestamp":1784871108687,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>\n                    Empyema necessitans (EN) is a rare complication of empyema, in which pus accumulates within the pleural space and spreads through the chest wall, leading to the formation of a subcutaneous abscess. This condition presents significant diagnostic and therapeutic challenges due to its rarity and potential for serious complications. Here, we present the case of an 8\u2010year\u2010old boy with a history of parapneumonic effusion that was incompletely treated due to a lack of fibrinolytic agent injection. He presented with fever, chills, a productive cough, and left\u2010sided chest pain with yellowish purulent secretions from the left chest wall. The patient was diagnosed with EN caused by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , which has occurred due to inadequate treatment and the lack of administration of a fibrinolytic agent injection for the patient. He was treated with broad\u2010spectrum antibiotics, video\u2010assisted thoracic surgery, and a chest tube for complete drainage. The patient showed a smooth and uneventful recovery, highlighting the importance of early diagnosis and prompt treatment of EN to avoid further complications. This case report aims to increase awareness among clinicians about the importance of early recognition and appropriate management of EN to improve patient outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.8697","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T07:45:50Z","timestamp":1711957550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Empyema necessitans as a rare manifestation of\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9159-3487","authenticated-orcid":false,"given":"Nazanin","family":"Zeinali\u00a0Nezhad","sequence":"first","affiliation":[{"name":"Physiology Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aazam","family":"Gholami\u00a0Shahrebabak","sequence":"additional","affiliation":[{"name":"Department of Medical Education, Medical Education Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Shahpar","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-021-01601-9"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2020.09.020"},{"issue":"2","key":"e_1_2_13_4_1","first-page":"224","article-title":"Empyema necessitans caused by methicillin\u2010resistant Staphylococcus aureus\u2014two rare presentations","volume":"46","author":"Ashraf S","year":"2022","journal-title":"Pak Pediatr J"},{"issue":"13","key":"e_1_2_13_5_1","first-page":"11","article-title":"Empyema necessitans secondary to tuberculosis: a case report","volume":"18","author":"Kumar A","year":"2022","journal-title":"Mal J Med Health Sci"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-202072"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103540"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/522996"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2016.04.005"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.09.019"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06452-6"},{"issue":"8","key":"e_1_2_13_13_1","article-title":"A complicated case of group B Streptococcus empyema necessitans","volume":"9","author":"Buell KG","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/108174"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000110625.41967.cc"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002555"},{"key":"e_1_2_13_17_1","first-page":"1","article-title":"Empyema necessitans in the setting of methicillin\u2010susceptible Staphylococcus aureus causing pneumonia and bacteremia","volume":"2018","author":"Bandaru S","year":"2018","journal-title":"Case Rep Infect Dis"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0000000000000839"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.165293"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.06.065"},{"key":"e_1_2_13_21_1","volume-title":"Nelson Textbook of 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Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:26:32Z","timestamp":1764253592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ccr3.8697"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8697","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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