{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:19:10Z","timestamp":1783113550081,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title>\n                  <jats:p>This case report illustrates that in\u00a0vitro fertilization (IVF) may be a potential risk factor for pregnancy\u2010associated osteoporosis (PAO), highlighting the need for awareness and monitoring of bone health in women undergoing IVF treatments. PAO is a rare disease resulting from an imbalance of calcium in the body during pregnancy and lactation and presenting with fragility fractures. PAO occurs in late pregnancy or early postpartum period. A 28\u2010year\u2010old woman who conceived through IVF experienced severe back pain 2\u2009days after delivery. Magnetic resonance imaging of the spine showed wedge\u2010shaped fractures of T9\u2010T12 vertebrae. Bone mineral density (BMD) was low on dual\u2010energy x\u2010ray absorptiometry. The laboratory tests were within the normal range. Based on the clinical manifestations, osteoporotic spine fracture, results of BMD, and exclusion of other causes of osteoporosis, the patient was diagnosed with PAO. Considering the deleterious effect of treatment with gonadotropin\u2010releasing hormone and repeated superovulation on bone, we hypothesized that IVF may be an etiological factor for PAO.<\/jats:p>","DOI":"10.1002\/ccr3.8702","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T23:44:45Z","timestamp":1711064685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy\u2010associated osteoporosis following in\u00a0vitro fertilization: A case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-1541","authenticated-orcid":false,"given":"Mehran","family":"Rahimi","sequence":"first","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz 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