{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:30:40Z","timestamp":1764253840508,"version":"3.46.0"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>Early recognition and treatment of Multisystem Inflammatory Syndrome in Children (MIS\u2010C) within the context of COVID\u201019 infection is crucial for improved outcomes. Prompt intervention with IVIG and steroids leads to significant improvement in a severe case of MIS\u2010C. Clinicians should be vigilant for MIS\u2010C symptoms and initiate timely management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>We report a case involving a fourteen\u2010year\u2010old male with COVID\u201019 infection who developed multisystem inflammatory disease. A previously healthy child presented with a history of 10\u2009days of fever and cough, along with diarrhea, and vomiting for 3\u2009days. His COVID\u201019 infection was confirmed through Polymerase Chain Reaction (PCR), and the laboratory values were remarkable for high levels of C\u2010reactive protein, D\u2010dimers, B\u2010type natriuretic peptide (BNP), and troponin I. He developed circulatory shock on the second day of the presentation and needed inotropic support. Steroids and intravenous immunoglobulin (IVIG) were started in light of Multisystem Inflammatory Syndrome in Children (MIS\u2010C), which improved his condition. Thus, during the management of COVID\u201019 infection, early detection and a careful clinical characterization for MIS\u2010C are essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8737","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T06:53:30Z","timestamp":1712127210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report on multisystem inflammatory syndrome in children (\n                    <scp>MIS\u2010C<\/scp>\n                    ) associated with\n                    <scp>COVID<\/scp>\n                    \u201019 infection"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-5972","authenticated-orcid":false,"given":"Roshan","family":"Bhandari","sequence":"first","affiliation":[{"name":"Maharajgunj Medical Campus, Institute of Medicine Tribhuvan University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Paudyal","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus, Institute of Medicine Tribhuvan University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhigya","family":"Paudyal","sequence":"additional","affiliation":[{"name":"KIST Medical College and Teaching Hospital Tribhuvan University  Lalitpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya Singh","family":"Beniwal","sequence":"additional","affiliation":[{"name":"Lady Hardinge Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Multisystem Inflammatory Syndrome in Children (MIS\u2010C) Associated with Coronavirus Disease 2019 (COVID\u201019) [Internet].2020Centers for Disease Control and Prevention. Accessd August 21 2020. Available from:https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp?%20deliveryName=USCDC_511\u2010DM28431"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352-4642(20)30215-7"},{"key":"e_1_2_12_4_1","unstructured":"COVID\u201019 Treatment Guidelines\u2010Special considerations in children [Internet]. U.S. Department of Health and Human Services.2020Accessed July 8 2020. Available from:https:\/\/www.covid19treatmentguidelines.nih.gov\/management\/clinical\u2010management\u2010of\u2010children\/special\u2010considerations\u2010in\u2010children\/"},{"key":"e_1_2_12_5_1","unstructured":"Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children (MIS\u2010C) [Internet].2020Centers for Disease Control and Prevention (CDC). Accessed July 8 2020. Available from:https:\/\/www.cdc.gov\/mis\/mis\u2010c\/hcp_cstecdc\/index.html"},{"key":"e_1_2_12_6_1","article-title":"CDC details COVID\u201019\u2010related inflammatory syndrome in children","volume":"14","author":"Jenco M","year":"2020","journal-title":"Am Acad Pediatr"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:26:40Z","timestamp":1764253600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ccr3.8737"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8737","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8737"}}