{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:18:04Z","timestamp":1788218284877,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>IgA pemphigus is usually treated by Dapsone. Recalcitrant cases may be treated by Colchicine, Sulfapyridine, or Acitretin. Some patients with recurrent severe disease may not respond to the aforementioned medications. Our study highlights the role of TNFa inhibitor as an alternative modality in the treatment of recalcitrant IgA pemphigus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>IgA pemphigus is a rare autoimmune blistering disease characterized by a pruritic, annular, vesiculopustular eruption. In IgA pemphigus, there are IgA autoantibodies targeting the keratinocyte cell surface adhesion molecules, causing cell\u2010to\u2010cell dehiscence and a flaccid vesiculopustular eruption, mainly in the axilla and groin. Dapsone, despite being the drug of choice for treating IgA pemphigus, is not effective in clearing lesions in a minority of patients and such rare cases of recalcitrant IgA pemphigus need alternative modalities of treatment. Here, we report the successful treatment of a 50\u2010year\u2010old male patient with an adalimumab injection who had a poor response to dapsone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8807","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T03:47:03Z","timestamp":1715744823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A case of IgA pemphigus, with a poor response to dapsone, successfully treated with adalimumab"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7324-0347","authenticated-orcid":false,"given":"Saman","family":"Al\u2010Zahawi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences (TUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz","family":"Kamyab","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, Razi Hospital Tehran University of Medical Sciences (TUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Balighi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences (TUMS)  Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center, Razi Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"IgA Pemphigus","author":"Aslanova M","year":"2018"},{"key":"e_1_2_12_3_1","volume-title":"Dermatology e\u2010Book","author":"Bolognia JL","year":"2012"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142459"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70301-U"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16516"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15232"},{"key":"e_1_2_12_8_1","volume-title":"Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders of Childhood and Adolescence","author":"Hurwitz S","year":"2016"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","DOI":"10.1177\/2050313X231181022","article-title":"IgA pemphigus following COVID\u201019 vaccination: a case report","volume":"11","author":"Lansang RP","year":"2023","journal-title":"SAGE Open Med Case Rep"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002408"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13341"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2018.02.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-018-8986-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0202-8"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0899-y"},{"key":"e_1_2_12_16_1","first-page":"e86","article-title":"Refractory atypical IgA pemphigus successfully treated with apremilast","volume":"51","author":"Zhou Y","year":"2023","journal-title":"J Dermatol"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.09.020"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.02.051"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.037"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T05:33:31Z","timestamp":1716960811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ccr3.8807"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8807","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2024-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8807"}}