{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:37Z","timestamp":1753862917649,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Key Clinical Message<\/jats:title><jats:p>Linezolid is a potent oxazolidinone for the treatment of various gram\u2010positive bacterial infections. However, the drug can cause potential adverse reactions such as thrombocytopenia, hyperlactacidemia and serotonin syndrome, which warrant consideration by the medical team when planning treatment. The existing literature has reported some adverse reactions caused by linezolid, but most of these are based on clinical characteristics and simple treatment measures. Two cases of linezolid overdose resulting in thrombocytopenia, hyperlactacidemia and serotonin syndrome are presented, which were successfully managed with therapeutic drug monitoring. A dose adjustment strategy was adopted to safely and effectively mitigate linezolid\u2010related adverse events.<\/jats:p>","DOI":"10.1002\/ccr3.8808","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:48:37Z","timestamp":1714178917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adverse reactions caused by high serum concentration of linezolid: Two case reports and literature review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-4607","authenticated-orcid":false,"given":"Renzhu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Xiangtan Central Hospital  Xiangtan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Children Health Care The Maternity and Children Health Hospital Of Xiangtan City  Xiangtan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Xiangtan Central Hospital  Xiangtan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wencan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Xiangtan Central Hospital  Xiangtan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Xiangtan Central Hospital  Xiangtan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"issue":"16","key":"e_1_2_13_2_1","first-page":"5706","article-title":"A case of linezolid\u2010induced SIADH in elderly and a review of the literature","volume":"26","author":"Dong QW","year":"2022","journal-title":"Eur Rev med Pharmacol Sci"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10050530"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12797"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06050-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000710"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S164515"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001478"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1335305"},{"key":"e_1_2_13_10_1","unstructured":"Administration USFD: FDA Adverse Event Reporting System (FAERS). 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