{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:33:59Z","timestamp":1786977239139,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>Hemophilic pseudotumors are rare complications occurring in individuals with severe hemophilia, characterized by progressive cystic swellings in muscles and\/or bones due to recurrent bleeding. Timely initiation of factor VIII replacement is crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Hemophilic pseudotumors are rare complications occurring in individuals with severe hemophilia, characterized by progressive cystic swellings in muscles and\/or bones due to recurrent bleeding. Although their incidence has decreased with the advent of factor VIII replacement therapy, they still create challenges, particularly in regions with limited access to medical care. Here, we present a case report of a hemophilic pseudotumor of the knee joint in a 15\u2010year\u2010old male with hemophilia A. The patient presented with severe left knee pain, swelling, and restricted range of motion, prompting further investigation. Imaging studies revealed lytic lesions, and MRI bone signal changes consistent with hemophilic pseudotumors. Prompt initiation of factor VIII replacement therapy and supportive management led to a significant improvement in symptoms and joint functionality. Follow\u2010up after 2\u2009months showed that the swelling had significantly reduced in size, with marked improvement in the functionality of the knee joint. This case confirms what is already known in the hemophilia literature: how important it is to prevent, diagnose, and treat pseudotumors early in hemophilia. However, longer clinical and imaging follow\u2010up of this case is necessary to determine whether the complaints associated with pseudotumors resolve with hematologic treatment or will require surgical treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.8822","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T08:10:01Z","timestamp":1714464601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hemophilic pseudotumor of the knee joint: Emphasizing prevention and early diagnosis in a rare disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-2037","authenticated-orcid":false,"given":"Shritik","family":"Devkota","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Anil Baghi Hospital  Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6808-1116","authenticated-orcid":false,"given":"Sugat","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Shreegaun Primary Health Care Center  Dang Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4839-5116","authenticated-orcid":false,"given":"Samiksha","family":"Lamichhane","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging B. P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-1330","authenticated-orcid":false,"given":"Dipendra","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Tuberculosis Treatment Center  Pokhara Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhola","family":"Bika","sequence":"additional","affiliation":[{"name":"Tokha Chandeshwari Hospital  Tokha Saraswati Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayeri Roy","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Radiology Aster DM Healthcare  Dubai UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tajinder","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Anil Baghi Hospital  Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4236\/IJCM.2012.33046"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2000.1.241"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-683169"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830450202"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20150440"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00609.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.1.1830055"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.144238"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.22038\/abjs.2019.40547.2090"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00577.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029610366433"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.150.2.349"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050268"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197557080-00020"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.158.1.1727336"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.13174"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T01:34:36Z","timestamp":1716946476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ccr3.8822"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8822","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]},"assertion":[{"value":"2024-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8822"}}