{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:12:56Z","timestamp":1772068376030,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Giant cell tumor of bone (GCT) is a rare neoplasm which often presents as a lytic lesion in the epiphyseal region of long bones and which are usually accompanied by pain, swelling, and restricted movement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Giant cell tumor of bone (GCT) is a rare neoplasm that affects individuals in their third and fourth decades of life. Clinically, it often presents as a lytic lesion in the epiphyseal region of bones, notably the distal femur and proximal tibia. Radiologically, GCT appears as a distinct lytic lesion in the epiphyseal region. Histopathologically, GCTs are composed of mononuclear cells, macrophages, and multinuclear giant cells, indicative of osteoclastogenic stromal tumors. A 37\u2010year\u2010old man presented with left wrist pain, swelling, and restricted movement persisting for a year, worsening over the last 7\u2009months. Radiographic assessments revealed a distal radius bone mass involving the radiocarpal joint. Biopsy confirmed a GCT with extension into peripheral muscle. PET\/CT scan showed localized pathology without metastasis. Histopathologically, GCT exhibited multinucleated giant cells, spindle cells, and aneurysmal bone cyst\u2010like regions with coagulation necrosis. Surgical resection involved en\u2010bloc removal and reconstruction with a non\u2010vascularized radius bone graft. Postoperatively, the patient showed no complications at the one\u2010year follow\u2010up, suggesting successful intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8830","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:48:35Z","timestamp":1714178915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Giant cell tumor of distal radius: En bloc resection with allograft reconstruction: A case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9390-9880","authenticated-orcid":false,"given":"Parviz","family":"Ahangar","sequence":"first","affiliation":[{"name":"Shams Tabrizi Clinic  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9063-8435","authenticated-orcid":false,"given":"Alireza","family":"Rahimnia","sequence":"additional","affiliation":[{"name":"Taleghani Hospital Shahid Beheshti University of Medical Sciences and Health Services  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9162-8706","authenticated-orcid":false,"given":"Mohsen","family":"Akbaribazm","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Khoy University of Medical Sciences  Khoy Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-8101","authenticated-orcid":false,"given":"Abbas","family":"Khalilpour","sequence":"additional","affiliation":[{"name":"Department of Operating Room Khoy University of Medical Sciences  Khoy Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-651X","authenticated-orcid":false,"given":"Mohsen","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine Baqiyatallah University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1585-7731","authenticated-orcid":false,"given":"Hosein","family":"Pirmohamadi","sequence":"additional","affiliation":[{"name":"Trauma Research Center Baqiyatallah University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-021-01047-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000852"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00972-x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01112-9"},{"issue":"11","key":"e_1_2_11_6_1","article-title":"Management of tenosynovial giant cell tumor: a neoplastic and inflammatory disease","volume":"4","author":"Healey JH","year":"2020","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.04.015"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040857"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.152750"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2020.04.020"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11411-9"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T05:35:16Z","timestamp":1716960916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ccr3.8830"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8830","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]},"assertion":[{"value":"2024-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8830"}}