{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:07:37Z","timestamp":1780409257896,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Our case highlights the importance of recognizing acromegaly as a potential risk factor for venous thromboembolism (VTE). Despite a thorough thrombophilia workup yielding unremarkable results, further research is warranted to elucidate the underlying mechanisms linking acromegaly and thrombophilia. This understanding will aid in improving risk assessment and management strategies for patients with acromegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Acromegaly, a rare disorder characterized by excessive growth hormone secretion, is associated with various comorbidities including hypertension, diabetes mellitus, and obstructive sleep apnea. While previous studies have identified abnormalities in hemostatic factors in acromegaly patients, the association between acromegaly and venous thromboembolism (VTE) remains poorly understood. We present the case of a 36\u2010year\u2010old male with a history of acromegaly who presented with acute dyspnea, chest pain, and cough. Despite a prior trans\u2010sphenoidal hypophysectomy, his acromegaly symptoms persisted. Upon evaluation, he was found to have bilateral pulmonary embolism. Thorough thrombophilia workup was unremarkable, suggesting acromegaly as a potential risk factor for VTE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8867","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T02:08:57Z","timestamp":1715393337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unexplained massive pulmonary embolism in acromegaly patient: A case report"],"prefix":"10.1002","volume":"12","author":[{"given":"Usamah","family":"Al\u2010Anbagi","sequence":"first","affiliation":[{"name":"Medicine Department Hazm Mebaireek General Hospital, Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shybin","family":"Usman","sequence":"additional","affiliation":[{"name":"Medicine Department Hazm Mebaireek General Hospital, Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Saad","sequence":"additional","affiliation":[{"name":"Public Health Department Ministry of Public Health Health\u2010Qatar  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-4119","authenticated-orcid":false,"given":"Abdulqadir J.","family":"Nashwan","sequence":"additional","affiliation":[{"name":"Nursing Department, Hazm Mebaireek General Hospital Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7043.1"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-016-0754-x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.1.168"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.162545"},{"issue":"4","key":"e_1_2_13_6_1","first-page":"756","article-title":"Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality","volume":"98","author":"Cohen AT","year":"2007","journal-title":"Thromb Haemost"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu283"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-015-0300-0"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.d01-1743.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.911572"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.37029\/jcas.v1i1.13"},{"issue":"8","key":"e_1_2_13_12_1","first-page":"341","article-title":"A case of acromegaly with thrombosis and embolism","volume":"10","author":"Coffey WB","year":"1912","journal-title":"Cal State J Med"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-008-9088-4"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000154486.03017.35"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8573"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12767"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T05:31:46Z","timestamp":1716960706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ccr3.8867"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8867","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8867"}}