{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:35:55Z","timestamp":1781872555442,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Prompt identification and management of anti\u2010N\u2010methyl\u2010D\u2010aspartate receptor encephalitis in young patients with acute psychiatric symptoms, seizures, and neurological deficits are crucial. Timely immunomodulatory therapy is essential for positive outcomes and minimizing long\u2010term complications. High suspicion for this rare disorder is necessary for timely diagnosis and optimal care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Anti\u2010N\u2010methyl\u2010D\u2010aspartate (NMDA) receptor encephalitis is characterized by the presence of antibodies against the NMDA receptor, a crucial component of synaptic signaling. This autoimmune disorder often manifests with psychiatric symptoms, seizures, and neurological deficits. Early diagnosis is essential, as delayed treatment can result in severe complications. In this case, the patient received corticosteroids and intravenous immunoglobulin (IVIG), leading to a successful recovery with no lingering neurological abnormalities. The prompt initiation of treatment highlights the importance of recognizing this condition early. Anti\u2010NMDA receptor encephalitis is a rare autoimmune disorder that presents with a range of neurological symptoms. In this case report, we highlight the significance of early recognition and treatment by discussing the emergency room visit of a 23\u2010year\u2010old woman who presented with acute\u2010onset agitation, disorientation, and seizures. A 23\u2010year\u2010old woman, presented to the emergency room with acute\u2010onset agitation, disorientation, and seizures. Magnetic resonance imaging (MRI) scans revealed temporal lobe signal alterations and electroencephalogram (EEG) showed widespread activity slowing. Importantly, anti\u2010NMDA receptor antibodies were detected in both serum and cerebrospinal fluid, confirming the diagnosis of anti\u2010NMDA receptor encephalitis. This case report underscores the significance of understanding the presentation, diagnosis, and treatment of anti\u2010NMDA receptor encephalitis. Timely recognition and intervention are crucial for achieving favorable outcomes in patients with this rare but clinically important autoimmune disorder. Increased awareness among healthcare professionals is essential to ensure early diagnosis and prompt initiation of appropriate treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8870","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T06:25:04Z","timestamp":1715149504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case report of anti\u2010NMDA receptor encephalitis in a 23\u2010year\u2010old female with acute psychiatric symptoms"],"prefix":"10.1002","volume":"12","author":[{"given":"Elham Mohammed","family":"Khatrawi","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences College of Medicine, Taibah University  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-1829","authenticated-orcid":false,"given":"Priyadarshi","family":"Prajjwal","sequence":"additional","affiliation":[{"name":"Neurology Bharati Vidyapeeth Medical College Pune  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-4534","authenticated-orcid":false,"given":"Mohammed Dheyaa Marsool","family":"Marsool","sequence":"additional","affiliation":[{"name":"University of Baghdad, Al\u2010Kindy College of Medicine  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Das","sequence":"additional","affiliation":[{"name":"Internal Medicine RG Kar Medical College and Hospital  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Nagre","sequence":"additional","affiliation":[{"name":"Internal Medicine Topiwala National Medical College  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pugazhendi","family":"Inban","sequence":"additional","affiliation":[{"name":"Internal Medicine Government Medical College  Omandurar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Dheyaa Marsool","family":"Marsool","sequence":"additional","affiliation":[{"name":"University of Baghdad, Al\u2010Kindy College of Medicine  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5021-263X","authenticated-orcid":false,"given":"Omniat Amir","family":"Hussin","sequence":"additional","affiliation":[{"name":"Manhal University  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1192\/pb.bp.113.045518"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq113"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(08)70224-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09607-3"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.04.005"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02652-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5593"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(12)70310-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30244-8"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.8870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T05:32:24Z","timestamp":1716960744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.8870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ccr3.8870"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.8870","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2024-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e8870"}}