{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:57Z","timestamp":1753862937872,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Tumor\u2010induced osteomalacia is a rare but potentially serious disease with nonspecific misguiding manifestations that can result in a wrong diagnosis and being treated for rheumatologic or other similar diseases. In patients with unexpected fractures, resistant musculoskeletal pains, and hypophosphatemia, this diagnosis should be considered by the physicians and approached through a complete history taking, physical exam laboratory, and radiologic evaluation to give the opportunity of on\u2010time treatment to the patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Tumor\u2010induced osteomalacia (TIO) is an uncommon mesenchymal tumor that results in disproportionate phosphorus excretion, primarily leading to bone\u2010related symptoms. Laboratory, imaging, and histopathological evaluation can confirm this pathologic condition. In this case, we present the history and subsequent clinical parts of a 50\u2010year\u2010old woman who presented with an unusual presentation of generalized musculoskeletal pains and a right ankle mass. Her disease was diagnosed with multidisciplinary evaluation and was approached by a surgical treatment. The patient was treated with total resection of the tumor, which led to complete resolution of musculoskeletal and metabolic abnormalities, which were resolved following total tumor resection. TIO is a paraneoplastic disease that results in abnormal secretion of phosphatonins, particularly fibroblast growth factor 23 (FGF23). This can cause hypophosphatemia, hyperparathyroidism, lower bone density, and increased risk of pathologic fractures. These tumors are mostly cured by surgical \u00b1 radiotherapy. The present study aims to provide insight into the fact that a TIO diagnosis is not always straightforward. However, in suspicious cases such as unexplained hypophosphatemia, it should be considered to prevent delayed diagnosis of the progressive pathology. The earlier treatment can prevent several complications and reduce the risk of mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8885","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T08:53:30Z","timestamp":1716195210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual presentation of tumor\u2010induced osteomalacia mismanaged due to misdiagnosis: A literature review based on a case report"],"prefix":"10.1002","volume":"12","author":[{"given":"Mahdieh","family":"Fatollahzadeh","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza Aghaei","family":"Meybodi","sequence":"additional","affiliation":[{"name":"Evidence Based Medicine Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Pajavand","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-8395","authenticated-orcid":false,"given":"Moloud","family":"Payab","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-4427","authenticated-orcid":false,"given":"Mahbube","family":"Ebrahimpur","sequence":"additional","affiliation":[{"name":"Elderly Health Research Center Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3694-6863","authenticated-orcid":false,"given":"Pouya","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Tehran Heart Center Cardiovascular Disease Research Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314896"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.04.042"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.44"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00843-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-22-2116"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00355.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101545198"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-022-01005-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-022-03498-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913129109016242"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031512"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-020-05369-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4325"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000460"},{"key":"e_1_2_10_16_1","first-page":"3","article-title":"Tumor\u2010Induced Osteomalacia","volume":"7","author":"Kumar R","year":"2015","journal-title":"Transl Endocrinol Metabol"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10010002"},{"issue":"6","key":"e_1_2_10_18_1","first-page":"463","article-title":"Hypophosphatemic osteomalacia with plantar neurilemoma. 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