{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:24:35Z","timestamp":1773869075873,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Creutzfeldt\u2013Jakob disease is a neurodegenerative disorder caused by brain accumulation of a misfolded form of the cellular prion protein, whose diagnosis is challenging, particularly in early stages, due to the variability and nonspecificity of the clinical and radiological features. 18F\u2010fluorodeoxyglucose positron\u2010emitted tomography has the potential to be considered a crucial investigation in these patients, revealing metabolic abnormalities earlier than the conventional neuroimaging analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>A 59\u2010year\u2010old man, the military officer, was referred to our Units for the onset of neurological symptoms rapidly evolving within a month, characterized by akinetic mutism, constructional apraxia, and disorders of spatial orientation. Brain 18F\u2010fluorodeoxyglucose (18F\u2010FDG) positron\u2010emitted tomography (PET)\/CT depicted an asymmetric hypometabolism in the left fronto\u2010temporo\u2010parietal cortex, as well as in the left thalamus and the right cerebellar hemisphere, while the glucose metabolism appears to be preserved in the somatosensory cortex and the basal ganglia. Laboratory routine analyses, cerebrospinal fluid routine, infective tests, electroencephalography (EEG), and brain magnetic resonance (MR) were all unremarkable. A positive RT\u2010QuIC result on cerebro\u2010spinal fluid (CSF) was subsequently shown, without any pathogenic gene mutations and, therefore, the result was consistent with a diagnosis of sporadic Creutzfeld\u2013Jacob disease. The clinical evolution was quickly unfavorable, and the patient died about 4\u2009months after hospital admission. FDG PET\/computed tomography (CT) has the potential to be considered a crucial investigation in these patients, documenting metabolic changes long time before other diagnostic investigations such as CSF, EEG, brain CT, and brain MR, thus suggesting a greater sensitivity of glucose metabolic evaluation in the early stage of the disease in question.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8974","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T03:24:28Z","timestamp":1719631468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["18F\u2010FDG PET\/CT in early phase of sporadic Creutzfeldt\u2010Jacob disease: A case report"],"prefix":"10.1002","volume":"12","author":[{"given":"Giovanni","family":"Boero","sequence":"first","affiliation":[{"name":"Neurology Unit Hospital \u201cSS. Annunziata\u201d  Taranto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Lauriero","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, PET\/CT Centre Hospital \u201cG. Moscati\u201d  Taranto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donato","family":"Fusillo","sequence":"additional","affiliation":[{"name":"Neurology Unit Hospital \u201cSS. 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