{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:09:05Z","timestamp":1753862945448,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>This case highlights the importance of a definite diagnosis of an IgG4\u2010related chronic sclerosing duodenitis based on histological and radiological findings to rule out any malignancy in the mass. While dealing with patients having concentric duodenal thickening resulting in stricture formation, one should think of inflammatory etiology as well. IgG4\u2010related disease is one of these inflammatory disorders where we see soft tissue thickening without a large mass or any associated lymphadenopathy as in our case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Immunoglobulin G4\u2010related disease (IgG4\u2010RD) is distinguished as an infiltration of IgG\u20104\u2010positive plasmacytes involving inflammatory lesions across multiple organs which is accompanied by raised IgG4 levels in the serum. Several inflammatory disorders are recognized as part of the IgG4\u2010RD family based on shared histopathological features, which include Mikulicz's disease, chronic sclerosing sialadenitis, or Riedel's thyroiditis. Our case highlights a distinctive presentation of IgG4\u2010related diseases; a 58\u2010year\u2010old man presenting with duodenal stricture highly suspicious of a duodenal mass\/ampullary mass later found to be due to IgG4\u2010related sclerosing duodenitis with negative malignancy on biopsy. We present the diagnostic challenges faced and relevant findings noted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.8980","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T03:49:28Z","timestamp":1716868168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Duodenal stricture secondary to <scp>IgG4<\/scp>\u2010related chronic sclerosing duodenitis\u2014A case report with review of the literature"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-9207","authenticated-orcid":false,"given":"Khizer Masroor","family":"Anns","sequence":"first","affiliation":[{"name":"Medical College, The Aga Khan University  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa","family":"Salar","sequence":"additional","affiliation":[{"name":"Medical College, The Aga Khan University  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9067-1620","authenticated-orcid":false,"given":"Hashim","family":"Salar","sequence":"additional","affiliation":[{"name":"Medical College, The Aga Khan University  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faheemullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Radiology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasim Ahmed","family":"Memon","sequence":"additional","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Aman","sequence":"additional","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uffan","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khurram","family":"Minhas","sequence":"additional","affiliation":[{"name":"Department of Histopathology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasnain","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jehanzeb","family":"Shahid","sequence":"additional","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi 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