{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:48:01Z","timestamp":1775123281209,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070766"],"award-info":[{"award-number":["82070766"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>In addition to post\u2010transplant lymphoproliferative disorders, it is necessary to be alert to the drug\u2010resistant bacteria or fungal infection, especially <jats:italic>Talaromyces marneffei<\/jats:italic>, in kidney transplant patients who have failed antibiotic treatment and whose PET\u2010CT indicates high metabolic mass in the transplanted kidney with a large number of other organs and lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:italic>Talaromyces marneffei<\/jats:italic> (TM) is a rare pathogenic fungus that primarily affects individuals with compromised immune systems. Post\u2010transplant lymphoproliferative disorders (PTLD) are serious complications that can occur after solid organ and cell transplantation. Both TM infection and PTLD can invade the monocyte\u2013macrophage system and often manifest as extranodal masses. This case report describes a kidney transplant patient who presented with symptoms of frequent, urgent, and painful urination over 6\u2009months. Pulmonary CT scans revealed multiple nodules, and PET\u2010CT demonstrated enlarged lymph nodes in the lungs and the transplanted kidney. The clinical manifestations closely mimicked those of PTLD. The confirmation of TM was achieved through pathogen metagenomic next\u2010generation sequencing and renal biopsy. Unfortunately, despite receiving treatment with antifungal agents, anti\u2010infective therapy, the patient's condition did not respond favorably, ultimately resulting in their unfortunate demise due to COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9028","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T01:39:05Z","timestamp":1719020345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Talaromyces marneffei<\/i>: A challenging diagnosis in a kidney transplant patient"],"prefix":"10.1002","volume":"12","author":[{"given":"Sulin","family":"Luo","sequence":"first","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Kidney Disease Prevention and Control Technology  Hangzhou Zhejiang China"},{"name":"National Key Clinical Department of Kidney Diseases  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